Publications
2022
- Lowary, T. L.; Achkar, J. M. “Tailor Made: New Insights Into Lipoarabinomannan Structure May Improve TB Diagnosis” J. Biol. Chem. 2022, 298, 101678.
- Yang, S.; Chu, C.–J.; Lowary, T. L.; “De novo synthesis of 3,6-dideoxy sugars” Org. Lett. 2022, 24, 5614–5618.
- Shen, K.; Lowary, T. L. “Synthesis of the Mycobacterium tuberculosis Canetti Lipooligosaccharide II Nonasaccharide” Org. Lett. 2022, 24, 6428–6432.
- Forrester, T. J. B.; Nothof, J. T.; Koizumi, A.; Lowary, T. L.; Whitfield, C.; Kimber, M. S. “The mechanism of the retaining β-Kdo glycosyltransferase WbbB uses two discrete SN2 reactions with an intermediate adduct rearrangement step” Nat. Commun. 2022, 13, 6277.
- Vocadlo, D. J; Lowary, T. L.; Bertozzi, C. R.; Schnaar, R. L.; Esko, J. D. “Chemical Tools for Inhibiting Glycosylation” In Essentials in Glycobiology Fourth Edition, Varki, A.; Cummings, R. D.; Esko, J. D.; Stanley, P; Hart, G. W.; Aebi, M.; Mohnen, D.; Kinoshita, T.; Packer, N. H.; Prestegard, J. H.; Schnarr, R. L.; Seeberger, P. H. Cold Spring Harbor Laboratory Press, 2022, Chapter 55.
- Speciale, I.; Notaro, A.; Abergel, C.; Lanzetta, R.; Lowary, T. L.; Molinaro, A.; Tonetti, M.; Van Etten, J. L.; De Castro, C. “The Astounding World of Glycans Syntheszied by Giant Viruses”. Chem. Rev. 2022, 122, 15717–15766.
- Nguyen, L.; McCord, K. A.; Bui, D. T.; Bouwman, K. M.; Kitova, E. N.; Elaish, M.; Kumawat, D.; Daskhan, G. C.; Tomris, I.; Han, L.; Chopra, P.; Yang, T.-J.; Willows, S. D.; Mason, A. L.; Mahal, L. K.; Lowary, T. L.; West, L. J.; Hsu, S.-T. D.; Hobman, T.; Tompkins, S. M.; Boons, G.-J.; de Vries, R. P., Macauley, M. S.; Klassen, J. S. “Sialic Acid-Dependent Binding and Viral Entry of SARS-CoV-2” Nat. Chem. Biol. 2022, 18, 81–90.
- Kim, T.; Bell, M. R.; Thota, V. N.; Lowary, T. L. “One-pot regioselective diacylation of pyranoside 1,2-cis diols” J. Org. Chem. 2022, 87, 4894–4907.
- Kelly, S. D.; Williams, D. M.; Nothof, J. T.; Kim, T.; Lowary, T. L.; Kimber, M. S.; Whitfield, C.; “The biosynthetic origin of ribofuranose in bacterial polysaccharides”, Nat. Chem. Biol. 2022, 18, 530–537.
2021
- Angala, S. K.; Joe, M.; McNeil, M. R.; Lowary, T. L.; Liav, A.; Jackson, M. “Use of synthetic glycolipids to probe the number and position of arabinan chains on mycobacterial arabinogalactan” ACS Chem. Biol. 2021, 16, 20–26.
- Liang, X.-Y.; Yang, J.; Qiu, Z.-H.; Wang, L.; Lowary, T. L.; Fan, H.-J. S. “A 4,6-di-O-benzylidene-directed preparation of 2-deoxy-2-azido-α-D-galactopyranosides promoted by a 3-O-t-butyldimethylsilyl ether.” Carbohydr. Res. 2021, 500, 108237.
- Sojitra, M.; Sarkar, S.; Maghera, J.; Rodrigues, E.; Carpenter, E.; Seth, S.; Ferrer Vinals, D.; Bennett, N.; Reddy, R.; Khalil, A.; Xue, X.; Bell, M.; Zheng, R. B.; Ling, C.-C.; Lowary, T. L.; Paulson, J. C.; Macauley, M. S.; Derda, R. “Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage” Nat. Chem. Biol. 2021, 17, 806–816.
- Tcheng, M.; Cunha, V. L. S.; Ahmed, N.; Liu, X.; Smith, R. W.; Rea, K. A.; Akhtar, T. A.; D’Alessandro, A.; Vockley, J.; O’Doherty, G. A.; Lowary, T. L.; Spagnuolo, P. A. “Structure–activity relationship of avocadyne” Food & Function, 2021, 12, 6323–6333.
- Wang, L.; Lowary, T. L. “Synthesis of Structurally-Defined Polymeric Glycosylated Phosphoprenols as Potential Lipopolysaccharide Biosynthetic Probes” Chem. Sci. 2021, 12, 12192–12200.
- Ishida, E.; Corrigan, D. T.; Malonis, R. J.; Hofmann, D.; Chen, T.; Amin, A. G.; Chatterjee, D.; Joe, M.; Lowary, T. L.; Lai, J. R.; Achkar, J. M. “Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes” Commun. Biol. 2021, 4, 1181.
- Bentall, A.; Jeyakanthan, M.; Braitch, M.; Cairo, C. W.; Lowary, T. L.; Maier, S.; Motyka, B.; West, L. J.; Zou, L.; Ball, S. “Characterization of ABH-subtype donor-specific antibodies in ABO-A-incompatible kidney transplantation” Am. J. Transplant. 2021, 21, 3649–3662.
- Anso, I.; Basso, L. G. M.; Wang, L.; Marina, A.; Páez-Pérez, E. D.; Jäger, C.; Gavotto, F.; Tersa, M; Perrone, S.; Contreras, F.-X.; Prandi, J.; Gilleron, M.; Linster, C. L.; Corzana, F.; Lowary, T. L.; Trastoy*, B.; Guerin*, M. E. “Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA” Sci. Adv. 2021, 7, eabj4565.
- Shen, K.; Bai, B.; Liu, Y.-H.; Lowary, T. L. “Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii” Angew. Chem. Intl. Ed. 2021, 60, 24859–24863.
2020
- Han, L.; Xue, X.; Roy, R.; Kitova, E. N.; St-Pierre, Y.; Lowary, T. L. “Neoglycolipids as Glycosphingolipid Surrogates for Protein Binding Studies Using Nanodiscs and Native Mass Spectrometry” Anal. Chem. 2020, 92, 14189–14196.
- Broger, T.; Nicol, M. P.; Sigal, G. B.; Gotuzzo, E.; Zimmer, A. J. Surtie, S.; Caceres-Nakiche, T.; Mantsoki, A.; Reipold, E. I.; Székely, R.; Tsionsky, M.; Plisova, T.; Chikamatsu, K.; Lowary, T. L.; Pinter, A.; Mitarai, S.; Moreau, E.; Schumacher, S. G.; Dekinger, C. M. “Diagnostic accuracy of 3 urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients” J. Clin. Invest. 2020, 130, 5756–5764.
- Speciale, I.; Laugieri, M. W.; Noel, E.; Lin, S.; Lowary, T. L.; Molinaro, A.; Duncan, G. D.; Agarkova, I. V.; Garozzo, D.; Tonetti, M. G.; Van Etten, J. L.; De Castro, C. “Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans” Proc. Natl. Acad. Sci. U.S.A., 2020, 117, 28735–28742.
- Huang, B.-S.; Lowary, T. L. “A Siloxane-Bridged Glycosyl Donor Enables Highly Stereoselective -Xylulofuranosylation” J. Org. Chem. 2020, 85, 15895–15907.
- Wang. L.; Lowary, T. L. “Synthesis of Rhamnolipid Derivatives Containing Ester Isosteres” Org. Lett. 2020, 22, 9633–9637.
- Clarke, B. R.; Ovchinnikova, O. G.; Sweeney, R. P.; Kamski-Hennekam, E.; Gitalis, R.; Mallette, E.; Lowary, T. L. Kelly, S. D.; Kimber, M. S.; Whitfield, C. “A bifunctional O-antigen polymerase structure reveals a new family of galactofuranosyltransferases” Chem. Biol.2020, 16, 450–457.
- Shen, L.; Viljoen, A.; Villaume, S.; Joe, M.; Chêne, L.; Méry, A.; Fabre, E.; Takegawa, K.; Lowary, T. L.; Vincent, S. P.; Kremer, L.; Guérardel, Y.; Mariller, C. “GlfH1, an endogenous remodeling galactofuranosidase that hydrolyzes mycobacterial arabinogalactan” Biol. Chem. 2020, 295, 5110–5123.
- Chen, T.; Blanc, C.; Liu, Y.; Ishida, E.; Xu, J.; Joe, M.; Jenny-Avital, E. R.; Chan, J.; Lowary, T. L.; Achkar, J. “Importance of capsular glycan recognition in human antibody-mediated immunity against Mycobacterium tuberculosis” Clin. Invest. 2020, 130, 1808–1822.
- Huang, B.-S.; Lowary, T. L. “β-Selective Xylulofuranosylation Via a Conformationally-Restricted Glycosyl Donor” Biomol. Chem. 2020, 8, 2264–2273.
- Tan, Y. Z.; Zhang, L.; Rodrigues, J.; Zheng, R. B.; Giacometti, S. I.; Rosario, A. L. Kloss, B.; Dandey, V. P.; Wei, H.; Brunton, R.; Raczkowski, A. M.; Athayde, D.; Catalão, M. J.; Pimentel, M.; Clarke, O. B.; Lowary, T. L.; Archer, M.; Niederweis, M.; Potter, C. S.; Carragher, B.; Mancia, F. “Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria” Cell 2020,78, 683–699.
- Tan, Y. Z.; Rodrigues, J.; Keener, J. E.; Zheng, R. B.; Brunton, R.; Kloss, B.; Giacometti, S. I.; Rosário, A. L.; Zhang, L.; Niederweis, M.; Clarke, O. B.; Lowary, T. L.; Marty, M. T.; Archer, M.; Potter, C. S.; Carragher, B.; Mancia, F. “Cryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis” Nat. Comm. 2020, 11, 3396.
- Lin, S.; Lowary, T. L. “Synthesis of a Highly Branched Nonasaccharide Chlorella Virus N-Glycan using a “Counter-Clockwise” Assembly Approach” Lett. 2020, 22, 7645–7649.
2019
- Doyle, L.; Ovchinnikova, O. G.; Myler, K.; Mallette, E.; Huang, B.-S.; Lowary, T. L.; Kimber, M. S.; Whitfield, C. “Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules” Nat. Chem. Biol. 2019, 15, 632–640.
- Palcekova, Z.; Angala, S. K.; Belardinelli, J. M.; Eskandarian, H. A.; Joe, M.; Brunton, R.; Rithner, C.; Jones, V.; Nigou, J.; Lowary, T. L. Gilleron, M.; McNeil, M. R.; Jackson, M. “Disruption of the SucT acyltransferase in Mycobacterium smegmatis abrogates succinylation of cell envelope polysaccharides” J. Biol. Chem. 2019, 294, 10325–10335.
- Kelly, S. D.; Clarke, B. R.; Ovchinnikova, O. G.; Sweeney, R. P.; Williamson, M. L.; Lowary, T. L.; Whitfield, C. “Klebsiella pneumoniae O1 and O2ac antigens provide prototypes for an unusual strategy for diversification of polysaccharide antigens” J. Biol. Chem. 2019, 294, 10863–10876.
- Broger, T.; Sossen, B.; du Toit, E.; Kerkhoff, A. D.; Schutz, C.; Reipold, E. I.; Ward, A.; Barr, D. A.; Macé, A.; Trollip, A.; Burton, R.; Ongarello, S.; Pinter, A.; Lowary. T. L.; Boehme, C.; Nicol, M. P.; Meintjes, G.; Denkinger, C. “Novel high sensitivity tuberculosis point-of-care test for people living with HIV” Lancet Infect. Dis. 2019, 19, 852–861.
- Cunha, V. S.; Liu, X.; Lowary, T. L.; O’Doherty, G. A. “De Novo Asymmetric Synthesis of Avocadyne, Avocadene and Avocadane Stereoisomers”. J. Org, Chem. 2019, 84, 15718–15725.
- Angala, S. K.; Li, W.; Palčeková, Z.; Zou, L.; Lowary, T. L.; McNeil, M. R. Jackson, M. “Cloning and partial characterization of an endo-α-(1→6)-D-mannanase gene from Bacillus circulans”. Int. J. Mol. Sci. 2019, 20, 6244.
- Sweeney, R. P.; Lowary, T. L. “New Insights into Lipopolysaccharide Assembly and Export” Curr. Opin. Chem. Biol. 2019, 53, 37–43.
- Sweeney, R. P.; Lowary, T. L. “A Route to Polyprenol Pyrophosphate-Based Probes of O-Polysaccharide Biosynthesis in Klebsiella pneumoniae O2a” Org Lett. 2019, 21, 1050–1053.
- Gao, Z.; Ovchinnikova, O. G.; Huang, B.-S.; Liu, F.; Williams, D. E.; Andersen, R. J.; Lowary, T. L.; Whitfield, C.; Withers S. G. “A High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors” J. Am. Chem. Soc. 2019, 141, 2201–2204.
- Speciale, I.; Duncan, G. A.; Unione, L.; Agarkova, I. V.; Garozzo, D.; Jimenez-Barbero, J.; Lin, S.; Lowary, T. L.; Molinaro, A.; Noel, E.; Laugieri, E.; Tonetti, M.; Van Etten, J. L; De Castro, C. “New Glycan Structures of Chlorovirus PBCV-1 Major Capsid Protein: Antigenic Variants Help Identify Virus-Encoded Glycosyltransferases” J. Biol. Chem. 2019, 294, 5688–5699.
- Tsionksy; M.; Mathew; A.; Lowary; T. L.; Pinter; A.; Plisova; T.; Bartlett; D.; Barbero, S.; Denkinger. C. M.; Moreau, E.; Katsuragi, K.; Kawasaki; M.; Nahid; P.; Sigal, G. B.; Broger, T. “Sensitive Electrochemiluminescence (ECL) Immunoassays for Detecting Lipoarabinomannan (LAM) and ESAT-6 in Urine and Serum from Tuberculosis Patients” PLOS One. 2019, 14, e0215443.
- Aboussafy, C. L.; Andersen Gersby, L. B.; Molinaro, A.; Newman, M.-A.; Lowary, T. L. “A Convergent Route to Enantiomers of the Bicyclic Monosaccharide Bradyrhizose Leads to Insight into the Bioactivity of an Immunologically Silent Lipopolysaccharide” J. Org. Chem. 2019, 84, 14–41.
2018
- Ati, J.; Colas, C.; Lafite, P.; Zheng, R. B.; Sweeney, R. P.; Lowary, T. L.; Daniellou, R. “The LGP1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties” Sci. Rep. 2018, 8, 17566.
- Sigal, G. B.; Pinter, A.; Lowary, T. L.; Kawasaki, M.; Li, A.; Mathew A.; Tsionsky, M.; Zheng, R. B.; Plisova, T.; Shen, K.; Katsuragi, K.; Choudhary, A.; Honnen, W. J.; Nahid, P.; Denkinger, C. M.; Broger, T. “A novel sensitive immunoassay targeting the MTX-Lipoarabinomannan epitope meets the WHO’s performance target for Tuberculosis diagnosis” J. Clin. Microbiol. 2018, 56, e01338–18.
- Lin, S.; Lowary, T. L. “Synthesis of the highly branched hexasaccharide core of chlorella virus N-linked glycans” Chem Eur J. 2018, 57, 16992–16996.
- Thota, V. N.; Ferguson, M. J.; Sweeney, R. P.; Lowary, T. L. “Synthesis of the Campylobacter jejuni 81-176 strain capsular polysaccharide repeating unit reveals the absolute configuration of its O-methyl phosphoramidate motif” Angew. Chem. Intl. Ed. 2018, 57, 15592–15596.
- Zhang, L.; Shen, K.; Taha, H. A.; Lowary, T. L. “Stereocontrolled synthesis of alpha-xylofuranosides using a conformationally-restricted donor” J. Org. Chem. 2018, 83, 7659–7671.
- Amin, A. G.; De, P.; Spencer, J. S.; Brennan, P. J.; Daum, J.; Andre, B. G.; Joe, M.; Bai, Y.; Laurentius, L.; Porter, M.; Honnen, W. J.; Choudhary, A.; Lowary, T. L.; Pinter, A.; Chatterjee*, D. “Detection of Lipoarabinomannan in Urine and Serum of HIV-positive and HIV-negative TB Suspects using an improved Capture-Enzyme Linked Immuno Absorbent Assay and Gas Chromatography/Mass Spectrometry” Tuberculosis 2018, 111, 178–187.
- Jankute, M.; Alderwick, L. J.; Moorey, A. R.; Gurcha, S. S.; Eggeling, L.; Lowary, T. L.; Dell, A.; Pang, P-C.; Yang, T.; Haslam, S.; Besra, G. S. “The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the alpha-(1-5) arabinan backbone in the early stages of cell wall arabinan biosynthesis” Cell Surf. 2018, 2, 38–53.
- Chou, Y.; Kitova, E.; Joe, M.; Brunton, R. M.; Lowary, T. L.; Klassen, J. S; Derda, R. “Genetically-encoded fragment-based discovery (GE-FBD) of glycopeptide ligands for antibodies related to mycobacterial infections” Org. Biomol. Chem. 2018, 223–227.
- Daksan, G. C.; Tran, H-T.; Meloncelli, P. J.; Lowary, T. L.; West, L. J.; Cairo, C. W. “Construction of multivalent homo- and hetero-functional ABO blood group glycoconjugates using a trifunctional linker strategy” Bioconjugate Chem. 2018, 29, 343–362.
- Xue, X.; Zhang, R. B.; Koizumi, A.; Han, L.; Klassen, J. S.; Lowary, T. L. “Synthetic Polyprenol-Pyrophosphate Linked Oligosaccharides Are Efficient Substrates for Mycobacterial Galactan Biosynthetic Enzymes” Org. Biomol. Chem. 2018, 16, 1939–1957.
- Cocaud, C.; Zheng, B.; Lowary, T. L; Poisson, T.; Pannecoucke, X.; Nicolas, C.; Martin, O. R. “1-C-Phosphonomethylene- and 1-C-Difluorophosphonomethylene-1,4-imino-l-arabinitols as Galactofuranosyltransferase Inhibitors: A Comparison” Carbohydr. Res. 2018, 461, 45–50.
- Clarke, B. R.; Ovchinnikova, O. G.; Kelly, S. D.; Williamson, M. L.; Butler, J. E.; Liu, B.; Wang, L.; Gou, X.; Follador, R.; Lowary, T. L.; Whitfield, C. “Molecular basis for structural diversity in serogroup O2-antigen polysaccharides in Klebsiella pneumoniae” J. Biol. Chem. 2018, 293, 4666–4679.
- Yang, D.-M.; Chen, Y.; Sweeney, R.; Lowary, T.; Liang, X. “Stereocontrolled Synthesis of 2-Deoxy-Galactopyranosides via Isopropylidene-Protected 6-O-Silylated Donors” Org. Lett. 2018, 20, 2287–2290.
- Choudhary, A.; Patel, D.; Honnen, W.; Lai, Z.; Prattipati, R.; Zheng, R. B.; Hsueh, Y-C.; Gennaro, M. L.; Lardizabal, A.; Joe, M.; Bai. Y.; Shen, K.; Spencer, J.; Chatterjee, D.; Broger, T.; Lowary, T. L.; Pinter, A. “Characterization of the antigenic heterogeneity of lipoarabinomannan (LAM), the major surface glycolipid of Mycobacterium tuberculosis, and complexity of the humoral immune response towards this antigen” J. Immunol. 2018, 200, 3053–3066.
2017
- Prados-Rosales*, R.; Carreño, L.; Weinrick, B.; Lowary, T. L.; Baena, A.; Joe, M.; Bai, Y.; Chow, S.-K.; Kalscheuer, R.; Batista-Gonzalez, A.; Saavedra, N. A.; Chen, T.; Blanc, C.; Xu, J.; Jacobs Jr., W. R.; Chan, J.; Porcelli, S. A.; Achkar, J. M. Casadevall, A. “Arabinomannan-protein conjugates induce a protective response in mice that controls Mycobacterium tuberculosis dissemination” PLoS Pathogens. 2017, 13, e1006250.
- Angala, S. K; McNeil, M. R.; Shi, L.; Pham, H.; Zuberogoitia, S.; Nigou, J.; Boot, C. M.; Lowary, T. L.; Gilleron, M.; Jackson, M. “Biosynthesis of the methylthioxylose capping motif of lipoarabinomannan in Mycobacterium tuberculosis” ACS Chem. Biol. 2017, 12, 682–691.
- Williams, D. M.; Ovchinnikova, O. G.; Koizumi, A.; Mainprize, I. L.; Kimber, M. S.; Lowary, T. L.; Whitfield, C. “A single polysaccharide assembly protein that integrates polymerization, termination and chain-length quality control” Proc. Natl. Acad. Sci. U.S.A., 2017, 114, E1215–E1223.
- Fiege, B.; Leuthold, M.; Parra, F.; Dalton, K. P.; Meloncelli, P. J.; Lowary, T. L. Peters, T. “Epitope mapping of histo blood group antigens bound to norovirus VLPs using STD NMR experiments reveals fine details of molecular recognition” Glycoconjug. J. 2017, 34, 679–689.
- Cocaud, C.; Maujoin, A.; Rodrigues, N.; Zheng, R. B.; Buron, F.; Routier, S.; Lowary, T. L.; Nicolas, C.; Martin, O. R. “Triazole-Linked Iminosugars and Aromatic Systems as Simplified UDP-Galf Mimics: Synthesis and Preliminary Evaluation as Galf-transferase Inhibitors” Eur. J. Org. Chem. 2017, 6192–6201.
- Zheng, R.B.; Jégouzo, S. A. F.; Joe, M.; Bai, Y.; Tran, H. A.; Shen, K.; Saupe, J.; Xia, ; Ahmed, M. F.; Liu, Y.-H.; Patil, P. S.; Tripathi, A.; Hung, S.-C.; Taylor*, M. E.; Lowary, T. L.; Drickamer*, K. “Insights into mycobacteria interactions with the host innate immune system from a novel array of synthetic mycobacterial glycans.” ACS Chem. Biol. 2017, 12, 2990–3002.
2016
- Poulin, M. B.; Lowary, T. L. “Chemical Insight Into the Mechanism and Specificity of GlfT2, a Bifunctional Galactofuranosyltransferase from Mycobacteria” J. Org. Chem. 2016, 81, 8123–8130.
- Lowary, T. L. “Twenty Years of Mycobacterial Glycans. Furanosides and Beyond.” Acc. Chem. Res. 2016, 49, 1379–1388.
- Joe, M.; Lowary, T. L. “Synthesis of a homologous series of galactofuranose-containing mycobacterial arabinogalactan fragments” Can. J. Chem. 2016, 94, 976–988.
- Frédéric, C.; Tikad, A.; Jian, F.; Pan, W.; Zheng, R. B.; Koizumi, A.; Xue, X.; Lowary, T. L.; Vincent, S P. “Synthesis of unprecedented sulfonylated phosphono-exo-glycals designed as inhibitors of the three mycobacterial galactofuranose processing enzymes” Chem. Eur. J. 2016, 22, 15913–15920.
- Ovchinnikova, O. G.; Doyle, L.; Huang, B.-S.; Kimber, M. S.; Lowary, T. L.; Whitfield, C. “Biochemical characterization of bifunctional 3-deoxy-β-D-manno-oct-2-ulosonic acid (β Kdo) transferase KpsC from Escherichia coli involved in capsule biosynthesis” J. Biol. Chem. 2016, 291, 21519–21530.
- Liu, L.; Siuda, I.; Richards, M. R.; Renaud, J.; Kitova, E. N.; Mayer, P. M.; Tieleman, D. P.; Lowary, T. L.; Klassen, J. S. “Structure and Stability of Carbohydrate–Lipid Complexes” ChemBioChem 2016, 17, 1571–1578.
- Li, J., Lowary, T. L. “Synthesis and evaluation of bicyclo[3.1.0]hexane-based UDP-Galf analogues as inhibitors of the mycobacterial galactofuranosyltransferase GlfT2” Molecules 2016, 21, 1053.
- Harrison, J.; Lloyd, G.; Joe, M.; Lowary, T. L. Reynolds, E.; Walters-Morgan, H.; Bhatt, A.; Lovering, A. L.; Besra, G. S.; Alderwick, L. J. “PagL is a phosphotransferase responsible for ligating arabinogalactan to peptidoglycan in Mycobacterium tuberculosis” mBio, 2016, 7, e00972-16.
- Chen, T.; Blanc, C.; Eder, A. Z.; Prados-Rosales, R.; Oliveira-Souza, A. C.; Kim, R. S.; Joe, M.; Bai, Y.; Lowary, T. L.; Tanner, R.; Brennan, M. J.; Fletcher, H. A.; McShane, H.; Casadevall, A.; Achkar, J. M. “Association of Human Antibodies to Arabinomannan with Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction” J. Infect. Dis. 2016, 214, 300–310.
- Lin, S.; Ashmus, R. A.; Lowary, T. L. “An oxidation–amidation approach for the synthesis of glycuronamides” Eur. J. Org. Chem. 2016, 2653–2644.
- Angala, S. K.; McNeil, M. R.; Zou, L.; Liav, A.; Zhang, J.; Lowary, T. L.; Jackson, M. “Identification of a novel mycobacterial arabinosyltransferase activity which adds an arabinosyl residue to α-D-mannosyl residues” ACS Chem. Biol. 2016, 11, 1518–1524.
- Ovchinnikova, O. G.; Mallette, E.; Koizumi, A.; Lowary, T. L.; Kimber*, M. S.; Whitfield, C. “The structure and function of a prototype bacterial β-Kdo glycosyltransferase reveals a new glycosyltransferase family” Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E3120–E3129.
- Jeyakanthan, M.; Meloncelli, P. J.; Zou, L.; Lowary, T. L.; Larsen, I.; Maier, S; Tao, K.; Rusch, J.; Chinnock, R.; Shaw, N.; Burch, M.; Beddows, K.; Addonizio, L.; Zuckerman, W.; Pahl, E.; Rutledge, J.; Kanter, K. R. Cairo, C. W.; Buriak, J. M.; Ross, D.; Rebeyka, I.; West, L. J. “ABH-glycan microarray characterizes ABO subtype antibodies: fine specificity of immune tolerance after ABO-incompatible transplantation” Am. J. Transplant. 2016, 16, 1548–1558.
- Ashmus, R. A.; Jayasuriya, A. B.; Lim, Y. J.; O’Doherty, G. A. Lowary, T. L. “De novo asymmetric synthesis of a 6-O-methyl-D-glycero-L-gluco-heptopyranose-derived thioglycoside for the preparation of Campylobacter jejuni NCTC11168 capsular polysaccharide fragments” J. Org. Chem. 2016, 81, 3058–3063.
- Slaney, A.; Dijke, I. E.; Jeyakanthan, M.; Li, C.; Zou, L.; Plaza-Alexander, P. M.; Meloncelli, P. J.; Bau, J.; Allan, L.; Lowary, T.L.; West, L. J.; Cairo, C. W.; Buriak*, J. M. “Conjugation of A and B Blood Group Structures to Silica Microparticles for the Detection of Antigen-Specific B Cells” Bioconjug. Chem.2016, 27, 705–715.
- Schieck, E.; Lartigue, C.; Frey, J.; Vozza, N.; Miller, R.; Nene, V.; Muriuki, C.; Naessens, J.; Lowary, T. L.; Vashee, S.; Feldman, M. F.; Jores*, J. “Genome editing of Mycoplasma mycoides via genome transplantation and mutagenesis in yeast provides insights into the functional role of UDP-galactopyranose mutase and capsular galactan” Mol.Microbiol. 2016, 99, 55–70.
2015
- Jeyakanthan, M.; Tao, K. S.; Zou, L.; Meloncelli, P. J.; Lowary, T. L.; Suzuki, K., Boland, D.; Larson, I.; Burch, M.; Shaw, N.; Beddows, K.; Addonizio, L.; Zuckerman, W.; Afzali, B.; Kim, D. H.; Mengel, A. M.; Shapiro, A. M. J.; Burch, M.; West, L. J. “Chemical basis for qualitative and quantative differences between ABO blood groups: implications for organ transplantation” Am. J. Transplant. 2015, 15, 2602–2615.
- Gagnon, S. M. L.; Meloncelli, P. J.; Zheng, R. B.; Haji-Ghassemi, O.; Johal, A. R.; Borisova, S.; Lowary, T. L.; Evans, S. V. “High resolution structures of the human ABO(H) blood group enzymes in complex with donor analogs reveal that the enzymes utilize multiple donor conformations to bind substrates in a step-wise manner” J. Biol. Chem. 2015, 290, 428–437.
- Sahloul, K.; Lowary, T. L. “Development of an Orthagonal Protection Startegy for the Synthesis of Mycobacterial Arabinomannan Fragments” J. Org. Chem. 2015, 80, 11417-11434.
- Poopari, M. R.; Dezhahang, Z.; Shen, K.; Wang, L.; Lowary, T. L.; Xu, Y. “Absolute Configuration and Conformation of Two Fráter–Seebach Alkylation Reaction Products by Film VCD and ECD Spectroscopic Analyses” J. Org. Chem. 2015, 80, 428–437.
- Zhang, D.; Huang, P.; Zou, L.; Lowary, T. L.; Tan, M.; Jiang X. “Tulane virus recognizes the A-type III and B histo-blood group antigens” J. Virol. 2015, 89, 1419–1427.
- Lak, P.; Makeneni, S.; Woods, R. J.; Lowary, T. L. “Specificity of Furanoside–Protein Recognition through Antibody Engineering and Molecular Modeling” Chem. Eur. J. 2015, 21, 1138–1148.
- Liston, S. D.; Clarke, B. R.; Greenfield, L. K.; Richards, M. R.; Lowary, T. L.; Whitfield, C. “Domain interactions control complex formation and polymerase specificity in the biosynthesis of the Escherichia coli O9a antigen” J. Biol. Chem. 2015, 290, 1075–1085.
- Wang L.; Dong, M.; Lowary, T. L. “Synthesis of Unusual N-Acylated Aminosugar Fragments of Mycobacterium marinum Lipooligosaccharide IV” J. Org. Chem. 2015, 80, 2767–2780.
- Elsaidi, H. R. H.; Lowary, T. L. “Effect of phenolic glycolipids from Mycobacterium kansasii on proinflammatory cytokine release. A structure–activity relationship study” Chem. Sci.2015, 6, 3161–3172.
- Conde, P.; Rodriguez, M.; van der Touw, W.; Jimenez, A.; Burns, M.; Miller, J.; Brahmachary, M.; Chen, H.-M.; Boros, P.; Rausell-Palamos, F.; Yun, T. J.; Riquelme, P.; Rastrojo, A.; Aguado, B.; Stein-Streilein, J.; Tanaka, M.; Zhou, L.; Zhang, J.; Lowary, T. L.; Ginhoux, F.; Park, C. G.; Cheolho, C.; Brody, J.; Turley, S.; Lira, S.; Bronte, V.; Gordon, S.; Heeger, P.; Merad, M.; Hutchinson, J.; Chen, S- H.; Ochando, J. “DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance” Immunity, 2015, 42, 1143–1158.
- Bai, B.; Chu, C.-J.; Lowary, T. L. “Lipooligosaccharides from Mycobacteria. Structure, Function and Synthesis” Isr. J. Chem. 2015, 55, 360–372.
2014
- Arutyunov, D.; Singh, U.; El-Hawiet, A.; Dos Santos Seckler, H.; Nikjah, S.; Joe, M.; Bai, Y.; Lowary, T. L.; Klassen, J.S.; Evoy*, S.; Szymanski*, C. M. “Application of mycobacteriophage cell binding proteins for the detection of mycobacteria” Bacteriophage 2014, 4, e960346.
- Backus, K. M.; Dolan, M. A.; Barry, C. S.; Joe, M.; McPhie, P.; Boshoff, H. I. M.; Lowary, T. L.; Davis, B. G.; Barry III; C. E. “The Three Mycobacterium Tuberculosis Antigen 85 Isoforms have Unique Substrates and Activities Determined by Non-active Site Regions” J. Biol. Chem. 2014, 289, 25041-25053.
- Zhai, Y.; Dasog, M.; Snitynski, R. B.; Purkait, T. K.; Aghajamali, M.; Hahn, A. H.; Sturdy, C. B.; Lowary, T. L.; Veinot, J. G. C. “Water-soluble Photoluminescent D-Mannose and L-Alanine Functionalized Silicon Nanocrystals and Their Application to Cancer Cell Imaging” J. Mater. Chem. 2014, 2, 8427-8433.
- Ashmus, R. A.; Lowary, T. L. “Synthesis of Carbohydrate Methyl Phosphoramidates” Org. Lett. 2014, 16, 2518-2521.
- Elsaidi, H. R. H.; Lowary, T. L. “Inhibition of Cytokine Release by Mycobacterium tuberculosis Phenolic Glycolipid Analogs” ChemBioChem 2014, 15, 1176-1182.
- Li, J.; Lowary, T. L. “Sulfonium Ions as Inhibitors of the Mycobacterial Galactofuranosyltranserase GlfT2” Med. Chem. Comm. 2014, 5, 1130-1137.
- van Alphen, L.; Wenzel, C. Q.; Richards, M. R.; Fodor, C.; Ashmus, R. A.; Stahl, M.; Karlyshev, A. V.; Wren, B. W.; Stintzi, A.; Miller, W. G.; Lowary, T. L.; Szymanski, C. M. “Biological roles of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni” PLoS ONE 2014, 9, e87051.
- Poulin, M. B.; Shi, Y.; Protsko, C.; Dalrymple, Sanders, D. A. R.; Pinto, B. M.; Lowary, T. L. “Specificity of a UDP-GalNAc pyranose-furanose mutase. A potential therapeutic target for Campylobacter jejuni infections” ChemBioChem 2014, 15, 47-56.
- Snitynsky, R. B.; Lowary, T. L. “Synthesis of nitrogen-containing furanose sugar nucleotides for the use as enzymatic probes” Org. Lett. 2014,16, 212-215.
2013
- Lowary, T. L. “Context and Complexity: The Next Big Thing in Synthetic Glycobiology” 2013, 17, 990-996.
- Zhang, J.; Zou, L.; Lowary, T. L. “Synthesis of the tolerance inducing oligosaccharide lacto-N-fucopentaose III bearing an activated linker” ChemistryOpen, 2013, 2, 156-163.
- Elsaidi, H. R. Barreda, D. R.; Cairo, C. W.; Lowary, T. L. “Simplified mycobacterial phenolic glycolipid analogs modulate cytokine levels via Toll-Like receptor 2” ChemBioChem 2013, 14, 2153-2159.
- Xia, L.; Lowary, T. L. “Amphiphilic cytosolic glycans from mycobacteria. Occurence, lipid-binding properties, biosynthesis and synthesis” Biopolymers 2013, 99, 697-712.
- Ahmed, M. F.; Lowary, T. L. “Glycosylations with 2,3-Aziridinofuranose Derivatives” Tetrahedron 2013, 69, 4276-4284.
- Richards, M. R.; Bai, Y.; Lowary, T. L. “Comparison between DFT- and NMR-based conformational analysis of methyl galactofuranosides” Carbohydr. Res. 2013, 374, 103-114.
- Willis, L. M.; Stupak, J.; Richards, M. R.; Li, J.; Lowary, T. L.; Whitfield*, C. “Structure of a conserved glycolipid terminus for capsular polysaccharides synthesized by the ABC transporter-dependent pathway in Gram-negative pathogens” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 7868-7873.
- Taha, H. A.; Richards, M. R.; Lowary, T. L. “Conformational Analysis of Furanoside-Containing Mono- and Oligosaccharides” Chem. Rev. 2013, 113, 1851-1876.
- Xia, L.; Lowary, T. L. “Regioselective Polymethylation of α-(1-4)-linked Mannopyranose Oligosaccharides” J. Org. Chem. 2013, 78, 2863-2880.
- Plaza-Alexander, P.; Lowary T. L. “Synthesis of trisaccharides incorporating the α-Gal antigen functionalized for neoglycoconjugate preparation” ARKIVOC 2013, ii, 112-122. Invited contribution to special issue in tribute to Professor Richard R. Schmidt.
2012
- Peng, W.; Zou, L.; Bhamidi, S.; McNeil, M. R.; Lowary T. L. “The galactosamine residue in mycobacterial arabinogalactan is α-linked” J. Org. Chem. 2012, 77, 9826-9832.
- Greenfield, L. K.; Richards, M. R.; Vinogradov, E.; Wakarchuk, W. W.; Lowary T. L.; Whitfield, C. “Domain Organization of the Polymerizing Mannosyltransferases Involved in Synthesis of the Escherichia coli O8 and O9a Lipopolysaccharide O Antigens” J. Biol. Chem. 2012, 287, 38135-38149.
- Liu, L.; Bai, Y.; Sun, N.; Xia, L.; Lowary T. L.; Klassen, J. S. “Carbohydrate-Lipid Interactions. Affinities of Methylmannose Polysaccharides for Lipids in Aqueous Solution” Chem. Eur. J. 2012, 18, 12059-12067.
- Greenfield, L. K.; Richards, M. R.; Li, J.; Wakarchuk, W. W.; Lowary T. L. “Biosynthesis of the Polymannose Lipopolysaccharide O Antigens from Escherichia coliSerotypes O8 and O9a Requires a Unique Combination of Mannosyltransferase Modules in Single- and Multi-Active Site Enzymes” J. Biol. Chem. 2012, 287, 35078-35091.
- Zou, L.; Zheng, R. B.; Lowary T. L. “Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica.” Beilstein J. Org. Chem. 2012, 8, 1219-1226. Invited contribution to “Synthesis in the Glycosciences” Thematic Issue.
- Wheatley, R. W.; Zheng, R. B.; Richards, M. R.; Lowary T. L.; Ng, K. K. S. “Tetrameric structure of GlfT2 reveals a scaffold for the assemble of mycobacterial arabinogalactan” J. Biol. Chem. 2012, 287, 28132-28143.
- Xia, L; Zheng R. B.; Lowary T. L. “Revisiting the specificity of an α-(1,4)-mannosyltransferase involved in mycobacterial methylmannose polysaccharide biosynthesis” ChemBioChem 2012, 13, 1139-1151.
- Poulin, M. B.; Zhou, R.; Lowary T. L. “Synthetic UDP-galactofuranose analogs reveal critical enzyme-substrate interactions in GlfT2-catalyzed mycobacterial galactan assembly” Org. Biomol. Chem. 2012, 10, 4074-4087.
- Sarkar, S.; Tang, X. L.; Das, D.; Lowary, T. L.; Suresh, M. R. “A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings” PLOS One. 2012, 7, e32340.
2011
- Clarke, B. R.; Richards, M. R.; Greenfield, L. K.; Hou, D.; Lowary, T. L.; Whitfield, C. In vitro “Reconstruction of the Chain Termination Reaction in Biosynthesis of theEscherichia coli O9a O-polysaccharide; the Chain-length Regulator, WbdD, Catalyzes the Addition of Methyl Phosphate to the Non-reducing Terminus of the Growing Glycan” J. Biol. Chem. 2011, 286, 41391–41401.
- Peng, W.; Jayasuriya, A. B.; Imamura, A.; Lowary, T. L. “Synthesis of the 6-O-methyl-D-glycero-α-L-gluco-heptopyranose moiety present in the capsular polysaccharide from Campylobacter jejuni NCTC 11168” Org. Lett. 2011, 13, 5290-5293.
- Islam, S. M.; Richards, M. R.; Taha, H. A.; Byrns, S. C.; Lowary, T. L.; Roy, P. N. “Conformational analysis of oligoarabinofuranosides: overcoming torsional barriers with umbrella sampling” J. Chem. Theor. Comput. 2011, 7, 2989-3000.
- Higgins, M. A.; Ficko-Blean, E.; Meloncelli, P. J.; Lowary, T. L.; Borastan*, A. B. “The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate Antigen Hydrolyzing Enzymes” J. Mol. Biol. 2011, 411, 1017-1036.
- Imamura, A.; Lowary, T. L. “Methods for the Chemical Synthesis of Furanose Glycosides” Trends Glycosci. Glycotech. 2011, 23, 134-152.
- Slaney, A. M.; Wright, V. A.; Meloncelli, P. J.; Harris, K. D.; West, L. J.; Lowary, T. L.; Buriak, J. M. “Biocompatible Carbohydrate-Functionalized Stainless Steel Surfaces: A New Method for Passivating Biomedical Implants” ACS App. Mater. Interfaces. 2011, 3, 1601-1612.
- Meloncelli, P. J.; West, L. J.; Lowary, T. L. “Synthesis and NMR Studies on the ABO Histo-Blood Group Antigens: Synthesis of Type III and IV Structures and NMR Characterization of Type I–VI Antigens” Carbohydr. Res. 2011, 346, 1406–1426.
- Shi, W.; Lowary, T.L. “Effect of Carbohydrate Amino Group Modifications on the Cytotoxicity of Glycosylated 2-Phenyl benzo-β-thiophenes and 2-Phenyl benzo-β-furans” Bioorg. Med. Chem. Lett. 2011, 21, 2591-2596.
- Shi, W.; Lowary, T.L. “Structure-Activity Relationships in Glycosylated 2-Phenyl-indoles, 2-Phenyl-benzo-β-thiophenes and 2-Phenyl-benzo-β-furans as DNA Binding and Potential Anti-tumor Agents” Bioorg. Med. Chem. 2011, 19, 1779-1789.
- Taha, H. A.; Roy, P. N. Lowary, T. L. “Theoretical Investigations on the Conformation of the β-Arabinofuranoside Ring” J. Chem. Theory Comput. 2011, 7, 420-432.
- Harrison, J. A.; Ravindranathan Kartha, K. P.; Fournier, E. J. L.; Lowary, T. L.; Malet, C.; Nilsson, U. J.; Hindsgaul, O.; Schenkman, S.; Naismith, J. H.; Field, R. A. “Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries” Org. Biomol. Chem. 2011, 9, 1653-1660.
- Frigell, J.; Pearcey, J. A.; Lowary, T. L. Cumpstey, I. “Carbasugar analogues of galactofuranosides: Pseudodisaccharide mimics of fragments of mycobacterial arabinogalactan” Eur. J. Org. Chem. 2011, 1367-1375.
- Liu, C.; Richards, M. R.; Lowary, T. L. “Synthesis and NMR Spectroscopic Analysis of Acylated Pentasaccharide Fragments of Mycobacterial Arabinogalactan” Org. Biomol. Chem. 2011, 9, 165–176.
- Vembaiyan, K.; Pearcey, J. A.; Bhasin, M.; Lowary, T. L.; Zou, W. “Synthesis of sugar–amino acid–nucleosides as potential glycosyltransferase inhibitors” Bioorg. Med. Chem. 2011, 19, 58–66.
- Shi, W.; Marcus, S. L.; Lowary, T. L. “Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” Bioorg. Med. Chem. 2011, 19, 603–612.
2010
- Peltier, P.; Beláňová, M.; Dianišková, P.; Brennan, P. J.; Zhou, R.; Zheng, R. B.; Pearcey, J. A.; Joe, M.; Nugier-Chauvin, C.; Ferrières, V.; Lowary, T. L.; Daniellou, R.; Mikušová, K. “Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis” Chem. Biol. 2010, 17, 1267–1366.
- Meloncelli, P. J.; Lowary, T. L. “Synthesis of ABO Histo-blood Group Type I and II Antigens” Carbohydr. Res. 2010, 345, 2304–2321.
- Tam, P.-H., Lowary, T. L. “Mycobacterial lipoarabinomannan fragments as haptens for potential anti-tuberculosis vaccines” RSC Specialist Periodical Reports, Carbohydrates 2010, 36, 38–58.
- Poulin, M. B.; Lowary, T. L. “Methods to Study the Biosynthesis of Bacterial Furanosides” Methods Enzymol. 2010, 478, 389–411.
- Oppenheimer, M.; Poulin, M. B.; Lowary, T. L. Helm, R. R.; Sobrado, P. “Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus” Arch. Biochem. Biophys. 2010, 502, 31–33.
- Yang, G.; Li, J.; Liu, Y.; Lowary, T. L.; Xu, Y. “Determination of the Absolute Configurations of Bicyclo[3.1.0]hexane Derivatives via Electronic Circular Dichroism, Optical Rotation Dispersion and Vibrational Circular Dichroism Spectroscopy and Density Functional Theory Calculations” Org. Biomol. Chem. 2010, 8, 3777–3783.
- Imamura, A.; Lowary, T. L. “β-Selective Arabinofuranosylation Using a 2,3-O-Xylylene-protected Donor” Org. Lett. 2010, 12, 3686–3689.
- Liu, C.; Richards, M. R.; Lowary, T. L. “Probing the Effect of Acylation on Arabinofuranose Ring Conformation in Di- and Trisaccharide Fragments of Mycobacterial Arabinogalactan” J. Org. Chem. 2010, 75, 4992–5007.
- Szczepina, M. G.; Zheng, R. B.; Completo, G. C.; Lowary, T. L.; Pinto, B. M. “STD-NMR Studies of Two Acceptor Substrates of GlfT2, a Galactofuranosyltransferase from M. tuberculosis: Epitope Mapping Studies” Bioorg. Med. Chem. Lett. 2010, 18, 5123–5125.
- Yang, G.; Tran, H.; Fan, E.; Shi, W.; Lowary, T. L.; Xu, Y. “Determination of the Absolute Configurations of Synthetic Daunorubicin Analogues Using Vibrational Circular Dichroism Spectroscopy and Density Functional Theory” Chirality, 2010, 22, 734–743.
- Taha, H. A.; Castillo, N. C.; Sears, D. N. Wasylishen, R. E.: Lowary, T. L. Roy, P.-N. “Conformational analysis of arabinofuranosides: Prediction of 3JH,H using MD Simulations with DFT-derived Spin–Spin Coupling Profiles” J. Chem. Theory Comput. 2010, 6, 212–222.
- Tam, P.-H.; Lowary, T. L. “Epimeric and amino disaccharide analogs as probes of an alpha-(1,6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis” Org. Biomol. Chem. 2010, 8, 181–192.
- Poulin, M. B.; Nothaft, H.; Hug, I.; Feldman, M. F. Szymanski, C. M.; Lowary, T. L. “Characterization of a Bifunctional Pyranose–Furanose Mutase from Campylobacter jenuni 11168” J. Biol. Chem. 2010, 285, 493–501.
- Shi, W.; Marcus, S. L.; Lowary, T. L. “Synthesis and Antibacterial Activity of Aminosugar-Functionalized Intercalating Agents” Carbohydr. Res. 2010, 345, 10–22.
2009
- Pan, Y.; Lowary, T. L.; Tykwinksi, R.R. “Naturally Occurring and Synthetic Polyyne Glycosides” Can. J. Chem. 2009, 87, 1565–1582.
- Tam, P.-H., Lowary, T. L. “Recent Advances in Mycobacterial Cell Wall Glycan Biosynthesis” Curr. Opin. Chem. Biol. 2009, 13, 618–625.
- Szczepina, M. G.; Zheng, R. B.; Completo, G. C.; Lowary, T. L.; Pinto, B. M. “STD-NMR Studies Suggest that Two Acceptor Substrates for GlfT2, a Bifunctional Galactofuranosyltransferase Required for the Biosynthesis of Mycobacterium tuberculosis Arabinogalactan, Compete for the Same Binding Site” ChemBioChem 2009, 10, 2052–2059.
- Shi, W.; Coleman, R. S. Lowary, T. L. “Synthesis and DNA-Binding Affinity Studies of Glycosylated Intercalators Designed as Functional Mimics of the Anthracycline Antibiotics” Org. Biomol. Chem. 2009, 3709–3722.
- Murase, T.; Zheng, R. B.; Joe, M.; Bai, Y.; Marcus, S. L.; Lowary, T. L.; Ng, K. K. S. “Structural insights into host recognition of mycobacterial polysaccharides” J. Mol. Biol. 2009, 392, 381–392.
- Hou, D.; Taha, H. A.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Mechanism of 2-Deoxy-2-Thioaryl Glycoside Formation” J. Am. Chem. Soc. 2009, 131, 12937–12948.
- Richards, M. R.; Lowary, T. L. “Chemistry and Biology of Galactofuranose-Containing Polysaccharides” ChemBioChem 2009, 10, 1920–1938. Hou, D.; Lowary, T. L. “Recent Advances in the Synthesis of 2-Deoxy-glycosides” Carbohydr. Res. 2009, 344, 1910–1939.
- Hou, D.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to Furanosyl Azides and C-glycosides” Tetrahedron 2009, 65, 5916–5921.
- Meloncelli, P. J.; Lowary, T. L. “Synthesis of ABO Type V and VI Antigens” Aust. J. Chem. 2009, 62, 558–574.
- Meloncelli, P. J.; Martin, A. D.; Lowary, T. L. “Glycosyl iodides. History and recent advances” Carbohydr. Res. 2009, 344, 1110-1122.
- Carapito, R.; Imberty, A.; Jeltsch, J.-M.; Byrns, S. C.; Tam, P.-H.; Lowary, T. L.; Varrot, A.; Phalip, V. “Molecular basis of arabinobio-hydrolase activity in phytopathogenic fungi. Crystal structure and catalytic mechanism of Fusarium graminearum GH93 α-L-arabinofuranosidase” J. Biol. Chem. 2009, 284, 12285–12296
- Hou, D.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to 2,6-Dideoxy-pyranosides” J. Org. Chem. 2009, 74, 2278–2289. Selected as a Feature Article by JOC editor.
- Taha, H. A.; Castillo, N.; Roy, P.-N.;Lowary, T. L.”Conformational Studies of Methyl β-D-Arabinofuranoside Using the AMBER/GLYCAM Approach” J. Chem. Theory Comput. 2009, 5, 430-438.
2008
- Phillips, R. L.; Kim, I.-K.; Bradley E. Carson, B. E.; Tidbeck, B.; Bai, Y.; Lowary, T. L.; Bunz, U. H. F. “Sugar-substituted poly(para-phenyleneethynylenes) and their interaction with concanavalin A and bacteria” Macromolecules 2008, 41, 7316–7320.
- Rose, N. L.; Zheng, R. B.; Pearcey, J.; Zhou, R.; Completo, G. C.; Lowary, T. L. “Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase” Carbohydr. Res.2008, 343, 2130–2139.
- Completo, G. C.; Lowary, T. L. “Synthesis of galactofuranose-containing acceptor substrates for mycobacterial galactofuranosyltransferases” J. Org. Chem. 2008, 73, 4513–4525.
- Shi, L.; Zhou, R.; Liu, Z.; Lowary, T. L.; Seeberger, P. H.; Stocker, B. L.; Crick, D. C.; Khoo, K.-H.; Chatterjee, D. “Transfer of the first arabinofuranose residue to galactan is essential for mycobacterial viability” J. Bacteriol. 2008, 190, 5248–5255.
- Birch, H. J.; Alderwick, L. J.; Bhatt, A.; Rittmann, D.; Krumbach, K.; Singh, A.; Bai, Y.; Lowary, T. L. Eggeling, L.; Besra, G. S.“Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha-(1,3) arabinofuranosyltransferase” Mol. Microbiol. 2008, 69, 1191–1206.
- Hou, F.; Skogman, F.; Lowary, T. L. “Synthesis of 8-azidooctyl glycoside derivatives of the O-chain repeating unit of Escherichia coli O9a lipopolysaccharide and a methylated analogue” Carbohydr. Res. 2008, 343, 1779–1790.
- Li, J.; Lowary, T. L. “Synthesis of Bicyclo[3.1.0]hexane Derivatives as Conformationally-Restricted Analogues of beta-Arabinofuranosyl and arabino-Galactofuranosyl Rings” Org. Lett. 2008, 10, 881–884.
- Alfaro, J. A.; Zheng, R. B.; Persson, M.; Letts, J. A.; Polakowski, R.; Bai, Y.; Borisova, S. N.; Seto, N. O. L.; Lowary, T. L.; Palcic, M. M.; Evans, S. V. “ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes” J. Biol. Chem. 2008, 283, 10097–10108.
- Appelmelk, B. J.; den Dunnen, J.; Ummels, R.; Pak, M.; Larrouy-Maumus, G.; Nigou, J.; Gurcha, S. S.; Movahedzadeh, F.; Brown, E. J.; Eysink Smeets, M. M.; Besra, G. S.; Willemsen, P. T. J.; Lowary, T. L.; van Kooyk, Y.; Maaskant, J. J.; Stoker, N.; Ley, P. v. d.; Puzo, G.; Vandenbroucke-Grauls, C. M. J. E.; Wieland, C. W.; van der Poll, T.; Geijtenbeek, T.; van der Sar, A M.; Bitter. W. “The mannose cap of lipoarabinomannan is not important for mycobacterial virulence.” Cell. Microbiol. 2008, 10, 930–944.
- Tam, P.-H.; Besra, G. S.; Lowary, T. L. “Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1,6)-mannosyltransferase” ChemBioChem 2008, 267–278.
- Seo, M.; Castillo, N.; Ganzynkowicz, R.; Daniels, C. R.; Woods, R. J.; Roy, P.-N.; Lowary, T. L. “An approach for the simulation and modeling of flexible rings. Application to the alpha-D-arabinofuranoside ring, a key constituent of polysaccharides from Mycobacterium tuberculosis” J. Chem. Theory Comput. 2008, 4, 184–191.
- Belánová, M.; Dianišková, P.; Brennan, P. J.; Completo, G. C.; Rose, N. L. Lowary, T. L.; Mikušová, K. “Galactosyl Transferases in Mycobacterial Cell Wall Synthesis” J. Bacteriol. 2008, 190, 1141–1145.
2007
- Kim, H.-S.; Ng, E. S. M.; Zheng, R. B.; Whittal, R.; Schriemer, D. C.; Lowary, T. L. “Studies Toward the Development of Anti tuberculosis Vaccines Based on Mycobacterial Lipoarabinomannan” ACS Symp. Ser. 2007, 989, 184–197.
- Liu, C.; Skogman, F.; Cai, Y.; Lowary, T. L. “Synthesis of the ‘primer-adaptor’ trisaccharide moiety of Escherichia coli O8, O9 and O9a lipopolysaccharide” Carbohydr. Res. 2007, 342, 2818–2825.
- Hou, D.; Lowary, T. L. “Stereoselective synthesis of 2-Deoxy-furanosides from 2,3-Anhydro-furanosyl Thioglycosides” Org. Lett. 2007, 9, 4487–4490.
- Liu, C.; Skogman, F.; Cai, Y.; Lowary, T. L. “Synthesis of the ‘primer-adaptor’ trisaccharide moiety of Escherichia coli O8, O9 and O9a lipopolysaccharide” Carbohydr. Res. 2007, 342, 2818–2825.
- Sefzik, T.; Houseknecht, J. B.; Clark, T. M.; Prasad, S.; Lowary, T. L.; Gan, Z.; Grandinetti, P. J. “Solid State 17O-NMR in Carbohydrates” Chem. Phys. Lett. 2007, 434, 312–315.
- Fan, E.; Shi, W.; Lowary, T. L. “Synthesis of daunorubicin analogs containing truncated aromatic cores and unnatural monosaccharide residues” J. Org. Chem. 2007, 72, 2917–2928.
- Voehringer, D.; Stanley, S. A.; Cox, J. S.; Lowary, T. L.; Locksley*, R. M. “Identification of Intelectin-1 and -2 as Novel Stat6-dependent Genes Expressed in Lung and Intestine During Helminth Infection” Exp. Parasitol. 2007, 116, 458-466.
- Tam, P.-H.; Lowary, T. L. “Synthesis of a Panel of Deoxy and Methoxy Analogs of the alpha-Manp-(1,6)-a-Manp-O(CH2)7CH3 Acceptor Substrate for a Polyprenolphosphomannose-Dependent Mycobacterial Mannosyltransferase” Carbohydr. Res. 2007, 342, 1741-1772.
- Rademacher, C.; Shoemaker, G. K.; Kim, H.-S.; Zheng, R. B.; Taha, H.; Liu, C.; Nacario, R. C.; Schriemer, D. C.; Klassen, J. S.; Peters, T.; Lowary, T. L. “Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan. A model system for oligofuranoside-protein recognition” J. Am. Chem. Soc. 2007, 129, 10489–10502.
- Joe, M.; Bai, Y.; Nacario, R. C.; Lowary, T. L. “Synthesis of the Docosanasaccharide Arabinan Domain of Mycobacterial Arabinogalactan and a Proposed Octadecasaccharide Biosynthetic Precursor” J. Am. Chem. Soc. 2007, 129, 9885–9901.
2006
- Joe, M.; Lowary, T. L. “Synthesis of 2-Deoxy-2-fluoro Analogs of Polyprenyl beta-D-Arabinofuranosyl Phosphates” Carbohydr. Res. 2006, 341, 2723–2730.
- Bai, Y.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to alpha-D-Galactofuranosides” J. Org. Chem. 2006, 71, 9658-9671.
- Bai, Y.; Lowary, T. L. “Synthesis of a Pentasaccharide Fragment of Varianose, a Cell Wall Polysaccharide from Penicllium varians” J. Org. Chem. 2006, 71, 9672-9680.
- Mendlik, M. T.; Tao, P.; Hadad, C. M.; Coleman, R. S.; Lowary, T. L. “Synthesis of L-Daunosamine and L-Ristosamine Glycosides Via Photoinduced Aziridination. Conversion to Thioglycosides for Use in Glycosylation Reactions” J. Org. Chem. 2006, 71, 8059-8070.
- Joe, M.; Sun, D.; Taha, H.; Completo, G. C.; Croudace, J. E.; Lammas, D. A.; Besra, G. S.; Lowary, T. L. “The 5-Deoxy-5-Methylthio-Xylofuranose Residue in Mycobacterial Lipoarabinomannan. Absolute Stereochemistry, Linkage Position, Ring Conformation and Immunomodulatory Activity” J. Am. Chem. Soc. 2006, 128, 5059-5072.
- Rose, N. L.; Completo, G. C.; Lin, S.-J.; McNeil, M. R.; Palcic, M. M.; Lowary, T. L. “Expression, Purification and Characterization of a Galactofuranosyl-transferase Involved in Mycobacterium tuberculosis Arabinogalactan Biosynthesis” J. Am. Chem. Soc. 2006, 128, 6721-6729.
- Ridgway, K. M.; Shi, W.; Lin, S.-J.; Palcic, M. M.; Lowary, T. L. “Chemical and Chemoenzymatic Synthesis of a Trisaccharide Fragment of Tsukamurella paurometabola Lipoarabinomannan” Can J. Chem. 2006, 84, 642-649.
- Bai, Y.; Lin, S.-J.; Qi, G.; Palcic, M. M.; Lowary, T. L. “Synthesis of n-octyl 2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1,2)-3-amino-3-deoxy-beta-D-galactopyranoside, an analog of the H-disaccharide antigen” Carbohydr. Res.2006, 341, 1702-1707.
- Chang, G. X.; Lowary, T. L. ” An Olefin Cross Metathesis Approach to C -Disaccharide Analogs of the alpha–D-arabinofuranosyl-(1,5)-alpha–D-arabinofuranoside Motif Found in the Mycobacterial Cell Wall ” Tetrahedron Lett. 2006, 47, 4561-4564.
- Kim, H.-S.; Ng, E. S. M.; Zheng, R. B.; Whittal, R.; Schriemer, D. C.; Lowary, T. L. “Studies Toward the Development of Anti-tuberculosis Vaccines Based on Mycobacterial Lipoarabinomannan” ACS Symposium Series, 2006
2005
- Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. “Modified Mannose Disaccharides as Substrates and Inhibitors of a Polyprenol Monophosphomannose-Dependent alpha-(1,6)-Mannosyltransferase Involved in Mycobacterial Lipoarabinomannan Biosynthesis” Bioorg. Med. Chem. 2005, 13, 1083-1094.
- Cociorva, O. M.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. “Oligosaccharides as Inhibitors of Mycobacterial Arabinosyltransferases. Di- and Trisaccharides Containing C-3 Modified Arabinofuranosyl Residues “Bioorg. Med. Chem. 2005, 13, 1369-1379.
- Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. “Synthetic Disaccharide Analogs as Potential Substrates and Inhibitors of a Mycobacterial Polyprenol Monophosphomannose-Dependent alpha-(1,6)-Mannosyltransferase” Tetrahedron: Asymmetry 2005, 15, 553-567.
- Completo, G. C.; Ponto, J. A.; Lowary, T. L. “Synthesis of Oligosaccharide Fragments of the Lipoarabinomannan from Rhodocuccus ruber” J. Carbohydr. Chem. 2005, 24, 517-527.
- Tong, M.; Jacobi, C. E.; van de Rijke, F. M.; Kuijper, S.; van de Werken, S.; Lowary, T. L.; Hokke, C. H.; Appelmelk, B. J.; Nagelkerke, N. J. D.; Hans J. Tanke, van Gijlswijk, R. P. M.; Kolk, A. H. J.; Raap, A. K. “A Multiplexed and Miniaturized Serological Tuberculosis (TB) Assay Identifies Antigens that Discriminate Maximally Between TB and non-TB Sera” J. Immunol. Meth. 2005, 30, 154-163.
- Luu, T.; Shi, W.; Lowary, T. L.; Tykwinski, R. R. “A Divergent Synthesis of Triyne Natural Products and Glycosylated Analogues Using a Carbenoid Rearrangement” Synthesis 2005, 3167-3178.
- Fan, E.; Lowary, T. L.; McDonald, R. “(3S,1S)-3-Hydroxyl-3-isopropenyl-1-tert-butyldiphenylsiloxy-1,2,3,4 -tetrahydronaphthalene” Acta Cryst E 2005, 61, o4295-o4297.
2004
- Cociorva, O. M.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to the Preparation of C-2 Functionalized alpha-D-Arabinofuranosides” Tetrahedron 2004, 60, 1481-1489.
- Cociorva, O. M.; Lowary, T. L. “Synthesis of Oligosaccharides as Potential Inhibitors of Mycobacterial Arabinosyltransferases. Di- and Trisaccharides Containing C-5 Modified Arabinofuranosyl Residues” Carbohydr. Res. 2004, 339, 853-865.
- Centrone, C. A.; Lowary, T. L. “Sulfone and Phosphinic Acid Analogs of Decaprenolphosphoarabinose as Potential Anti-tuberculosis Agents” Bioorg. Med. Chem. 2004, 12, 5495-5503.
- Koppel. E. A.; Ludwig, I. S.; Sanchez-Hernandez, M.; Lowary, T. L.; Gadikota, R. R.; Bovin, N.; Vandenbroucke, C. M. J. E, van Looyk, Y.; Appelmelk, B. J.; Geijtenbeek, T. B. H. “Identification of the Mycobacterial Carbohydrate Structure That Binds the C-type Lectins DC-SIGN, L-SIGN, and SIGNR1 ” Immunobiol. 2004, 209, 117-127.
- Tilekar, J. N.; Lowary, T. L. “An Efficient Route to Thioglycosides with the 2,3-Anhydro-D–riboStereochemistry” Carbohydr. Res. 2004 , 339 , 2895-2899.
- Rhoad, J. S.; Lowary, T. L.; Ferguson, M. J. “5,6,7,9-Tetra-O -acetyl-4,8-anhydro-1,2,3-trideoxy-D–glycero–D–gulo-non-1-enitol ” Acta Cryst E. 2004, 60, o1939-o1941.
- Rhoad, J. S.; Lowary, T. L.; Ferguson, M. J. “4,8-Anhydro-1,2,3,5-tetradeoxy-D–allo-non-1-enitol ” Acta Cryst E. 2004, 60, o1942-o1944.
- Bai, Y.; Lowary, T. L.; Ferguson, M. J. “p -Tolyl 2,3-anhydro-5,6- O-isopropylidene-1-thio-beta-D-gulofuranoside” Acta Cryst E, 2004, 60, o2201-o2203.
2003
- Houseknecht, J. B.; Lowary, T. L.; Hadad, C. M. “Improved Karplus Equations for 3 J C1,H4 in Aldopentofuranosides. Application to the Conformational Preferences of the Methyl Aldopentofuranosides” J. Phys. Chem. A. 2003, 107, 372-378.
- Han, J.; Gadikota, R. R.; McCarren, P. R.; Lowary, T. L. “Synthesis of Octyl Arabinofuranosides as Substrates for Mycobacterial Arabinosyltransferases” Carbohydr. Res. 2003, 338, 581-588.
- Gadikota, R. R.; Keller, A. I.; Callam, C. S.; Lowary, T. L. “Efficient syntheses of trans -(+)-laurediol from carbohydrate precursors” Tetrahedron: Asymmetry 2003, 14,737-742.
- Gadikota, R. R.; Callam, C. S.; Appelmelk, B. J.; Lowary, T. L. “Synthesis of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan Appropriately Functionalized for Neoglycoconjugate Preparation” J. Carbohydr. Chem. 2003, 22, 459-480.
- Gadikota, R. R.; Callam, C. S.; Wagner, T.; Del Fraino, B.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Highly Stereocontrolled Synthesis of Oligosaccharides Containing alpha and beta Arabinofuranosyl Linkages” J. Am. Chem. Soc. 2003, 125, 4155-4165.
- Han, J.; Lowary, T. L. “Total Synthesis of Buergerinin F and Buergerinin G” J. Org. Chem. 2003, 68, 4116-4119.
- Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “An Efficient Route to Pyrimidine Nucleosides with the 2,3-Anhydro-beta-Dlyxofuranosyl Stereochemistry ” Synlett, 2003, 1271-1274.
- Houseknecht, J. B.; Lowary, T. L.; Hadad, C. M. “Gas and Solution Phase Energetics of the Methyl alpha and beta-D -aldopentofuranosides ” J. Phys. Chem. A. 2003, 107, 5763-5777.
- Centrone, C. A.; Lowary, T. L. “An Efficient Route for the Synthesis of Glycosyl Phosphinic Acids” J. Org. Chem. 2003, 68, 8115-8119.
- Callam, C. S.; Gadikota, R. R.; Krein, D. M.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. NMR and Computational Investigations into the Mechanism of Glycosylations with 2,3-Anhydrofuranosyl Glycosyl Sulfoxides” J. Am. Chem. Soc. 2003, 125, 13112-13119.
- Darwish, O.; Callam, C. S.; Hadad. C. M.; Lowary, T. L. “Regioselectivity in Alkylation Reactions of 1,2-O-Stannylene Acetals of D-Arabinofuranose” J. Carbohydr. Chem. 2003, 22, 955-973.
- Lowary, T. L. “Recent Progress Towards the Identification of Inhibitors of Mycobacterial Cell Wall Polysaccharide Biosynthesis” Mini-Rev. Med. Chem. 2003, 3, 694-707.
- Lowary, T. L. “Synthesis and Conformational Analysis of Arabinofuranosides, Galactofuranosides, and Fructofuranosides” Curr. Opin. Chem. Biol. 2003, 7, 749-756.
- Wagner, T.; Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “1-(2´,3´-anhydro-5´-O-benzoyl-beta-D-lyxofuranoyl)-5-fluoro-uracil ” Acta Cryst E. 2003, 59, o1063-o1065.
2002
- Lowary, T. L.; Eichler, E., Bundle, D. R. “Oligosaccharide Recognition by Antibodies: Synthesis and Evaluation of Talose Oligosaccharide Analogues” Can. J. Chem. 2002, 80, 1112-1130.
- Yin, H.; D’Souza, F. W.; Lowary, T. L. “Arabinofuranosides from Mycobacteria: Synthesis of a Highly Branched Hexasaccharide and Related Fragments Containing beta-Arabinofuranosyl Residues” J. Org. Chem. 2002, 67, 892-903.
- Lowary, T. L. “D-Arabinofuranosides from Mycobacteria: Synthesis and Conformation” J. Carbohydr. Chem. 2002, 21, 691-722.
- Houseknecht, J. B.; Lowary, T. L. “Oligofuranosides Containing Conformationally-Restricted Residues: Synthesis and Conformational Analysis” J. Org. Chem. 2002, 67, 4150-4164.
- Houseknecht, J. B.; Altona, C.; Hadad, C. M.; Lowary, T. L. “Conformational Analysis of Furanose Rings with PSEUROT: Parameterization for Rings Possessing the Arabino-, Lyxo-, Ribo– and Xylo– Stereochemistry and Application toArabinofuranosides ” J. Org. Chem. 2002, 67, 4647 -4651.
- Krein, D. M.; Lowary, T. L. “An Efficient Route to 2-(Alkylamino)pyridines” J. Org. Chem. 2002, 67, 4965-4967.
- Kaur, D.; Lowary, T. L.; Vissa, V. D.; Crick, D. C.; Brennan, P. J. “Characterization of the Epitope of Anti-lipoarabinomannan Antibodies as the Terminal Hexaarabinofuranosyl Motif of Mycobacterial Arabinans” Microbiology UK, 2002, 148, 3059-3067.
- Basak, P.; Lowary, T. L.”Synthesis of Conjugates of L -Fucose and ortho-Carborane as Potential Agents for Boron Neutron Capture Therapy” Can. J. Chem. 2002, 80, 943-948.
- Centrone, C. A.; Lowary, T. L. “Synthesis and Anti-tuberculosis Activity of C-Phosphonate Analogs of Decaprenolphosphoarabinose, A Key Intermediate in the Biosynthesis of Mycobacterial Arabinogalactan and Lipoarabinomannan” J. Org. Chem. 2002, 67, 8862-8870.
2001
- Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “An Efficient Synthesis of Methyl 2,3-anhydro-alpha-D-ribofuranoside“Carbohydr. Res. 2001, 330, 267-270.
- Callam, C. S.; Lowary, T. L. “Synthesis of Methyl 2,3,5-tri-O-benzoyl-alpha-D-arabinofuranoside in the Organic Laboratory ” J. Chem. Educ. 2001, 78, 73-74.
- Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “Stereocontrolled Synthesis of 2,3-Anhydro-beta-D-lyxofuranosyl Glycosides” Org. Lett. 2001, 3, 607-610.
- McGurk, P.; Chang, G. X.; Lowary, T. L.; McNeil, M.; Field, R. A. “Stereospecific Synthesis of 5-Phospho-alpha-D-arabinosyl-C– phosphonophosphate (pAC pp): A Stable Analogue of the Putative Mycobacterial Cell Wall Biosynthetic Intermediate 5-Phospho-D-arabinosyl Pyrophosphate” Tetrahedron Lett. 2001, 42, 2231-2234
- McCarren, P. R.; Gordon, M. T.; Lowary, T. L.; Hadad, C. M. “Computational Studies of the Arabinofuranose Ring: Conformational Preferences of Fully Relaxed Methyl alpha-D -arabinofuranoside ” J. Phys. Chem. A. 2001, 105, 5911-5922.
- Callam, C. S.; Lowary, T. L. “Suzuki Cross Coupling Reactions: Synthesis of Unsymmetrical Biaryls in the Organic Laboratory” J. Chem. Educ. 2001, 78, 947-948.
- Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “Sensitivity of 1JC1–H1 Magnitudes to Anomeric Stereochemistry in 2,3-Anhydro-O-furanosides” J. Org. Chem. 2001, 66, 4549-4558.
- Lowary, T. L. “Mycobacterial Cell Wall Polysaccharides: Structure, Function, Biosynthesis and New Opportunities for Drug Design” Invited Chapter in Glycoscience: Chemistry and Chemical Biology Fraser-Reid, B; Thiem, J.; Tatsuta, K. Eds. Springer-Verlag, 2001.
- Lowary, T. L. “D-Arabinofuranosides from Mycobacteria: Synthesis and Conformation” Invited Chapter in Glycochemistry: Synthesis and Applications Bertozzi, C. R.; Wang, P. Eds. Marcel-Dekker, 2001.
- Houseknecht, J. B.; Lowary, T. L. ” Chemistry and Biology of Arabinofuranosyl and Galactofuranosyl-Containing Polysaccharides ” Curr. Opin. Chem. Biol. 2001 , 5 , 677-682.
- Yin, H. F.; Lowary, T. L. “Synthesis of arabinofuranosides via low-temperature activation of thioglycosides” Tetrahedron Lett. 2001, 42, 5829-5832.
- Houseknecht, J. B.; McCarren, P. R.; Lowary, T. L.; Hadad, C. M. ” Conformational Studies of Methyl 3-O-Methyl-alpha-D-Arabinofuranoside: An Approach for Studying the Conformation of Furanose Rings” J. Am. Chem. Soc. 2001, 123, 8811-8824.
- Callam, C. S.; Singer, S. J.; Lowary, T. L.; Hadad, C. M. “Computational Analysis of the Potential Energy Surfaces of Glycerol in the Gas and Aqueous Phases. Effects of Level of Theory and Basis Set on Strongly Intramolecular Hydrogen-Bonded Systems ” J. Am. Chem. Soc. 2001, 123, 11743-11754.
- Callam, C. S.; Lowary, T. L. “Synthesis and Conformational Investigations of Methyl 4a-carba-D-arabinofuranosides“J. Org. Chem. 2001, 66, 8961-8972.
- Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “Total Synthesis of (6S,7S,9S,10S)-6,9-epoxynonadec-18-ene-7,10-diol and Formal Total Synthesis of (+)- trans-Kumausyne from D-Arabinose” J. Org. Chem. 2001, 66, 9046-9051.
2000
- Laferté, S.; Chan, N. W. C.; Sujino, K.; Lowary, T. L.; Palcic, M. M. “Intracellular Inhibition of Blood Group A Glycosyltransferase” Eur. J. Biochem. 2000, 267, 4840-4849.
- Callam, C. S.; Lowary, T. L. “Total Synthesis of Methyl 4a-carba-D-arabinofuranosides” Org. Lett. 2000, 2, 167-169.
- Davis, T. M.; Lowary, T. L. “Unexpected Formation of Glycals Upon Attempted C-alkylation of Protected Glycosylacetylenes” Carbohydr. Res. 2000, 324, 210-217.
- D’Souza, F. W.; Ayers, J. D.; McCarren, P. R.; Lowary, T. L. “Arabinofuranosyl Oligosaccharides from Mycobacteria: Synthesis and Effect of Glycosylation on Ring Conformation and Hydroxymethyl Group Rotamer Populations” J. Am. Chem. Soc. 2000, 122, 1251-1260.
- D’Souza, F. W.; Lowary, T. L. “The First Total Synthesis of a Highly Branched Arabinofuranosyl Hexasaccharide Found at the Nonreducing Termini of Mycobacterial Arabinogalactan and Lipoarabinomannan” Org. Lett. 2000, 2, 1493-1495.
- Chang, G. X.; Lowary, T. L. “A Glycosylation Protocol Based on Activation of Glycosyl 2-Pyridyl Sulfones with Samarium Triflate” Org. Lett. 2000, 2, 1505-1508.
- Gordon, M. T.; Lowary, T. L.; Hadad, C. M. “Probing Furanose Ring Conformation by Gas-Phase Computational Methods: Energy Profile and Structural Parameters in Methyl beta-D-arabinofuranoside as a Function of Ring Conformation” J. Org. Chem. 2000, 65, 4954-4963.
- Gallucci, J. C.; Gadikota, R. R.; Lowary, T. L. ” p-Cresyl 2,3-anhydro-5-deoxy-5-phthalimido-1-thio-alpha-D-lyxofuranoside ” Acta. Cryst. C. 2000, 56, e365.
1988 - 1998
1999
- Subramaniam, V.; Lowary, T. L. “Synthesis of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan from Mycobacterium tuberculosis” Tetrahedron, 1999, 55, 5965-5976.
- Gordon, M. T.; Lowary, T. L.; Hadad, C. M. “A Computational Study of Methyl alpha-D-Arabinofuranoside: Effect of Ring Conformation on Structural Parameters and Energy Profile” J. Am. Chem. Soc. 1999, 121, 9682-9692.
1998
- Lowary, T. L.; Meldal, M. Helmboldt, A.; Vasella, A.; Bock, K. “Novel Rigid Type of C-linked Glycosylacetylene Phenylalanine Building Blocks for Combinatorial Syntheses of C-Linked Glycopeptides” J. Org. Chem. 1998, 63, 9657-9668.
- St. Hilaire, P. M.; Lowary, T. L.; Meldal, M.; Bock, K. “Oligosaccharide Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide Libraries” J. Am. Chem. Soc. 1998, 120, 13312-13320.
- Ayers, J. D.; Lowary, T. L.; Morehouse, C. B.; Besra, G. S. “Recognition of Synthetic Synthetic Arabinofuranosyl Oligosaccharides by Mycobacterial Arabinosyltransferases ” Bioorg. Med. Chem. Lett. 1998, 8, 437-442.
- D’Souza, F. W.; Lowary, T. L. “A New Route to Carbohydrates Enriched with Oxygen Isotopes” J. Org. Chem. 1998, 63, 3166-3167.
- Bausch, C.; Peekhaus, N.; Utz, C.; Blais, T.; Murray, E.; Lowary, T. L.; Conway, T. “Post-Genomic Analysis of the GntII (Subsidiary) System for Gluconate Metabolism Reveals a Novel Pathway for L-Idonic Acid Catabolism in E. coli” J. Bacteriol. 1998, 180, 3704-3710.
- D’Souza, F. W.; Cheshev, P. E.; Ayers, J. D.; Lowary, T. L. “Conversion of Pyranose Glycals to Furanose Derivatives: A New Route to Oligofuranosides” J. Org. Chem. 1998, 63, 9037-9044.
1996
- Greis, K. D.; Hayes, B. K.; Comer, F. I.; Kirk, M.; Barnes, S.; Lowary, T. L.; Hart, G. W. “Selective Detection of Glycopeptides and Site Mapping by Electrospray Mass Spectrometry” Anal. Biochem. 1996, 234, 38-49.
1995
- Deng, S.-J.; McKenzie, C. R.; Hirama, T.; Brousseau, R.; Young, N. M.; Lowary, T. L.; Bundle, D. R.; Narang, S. A. “A Synthetic Gene Library Approach to the Enhancement of Antibody Affinity” Proc. Natl. Acad. Sci. USA 1995, 92, 4992-4996.
- Lowary, T. L.; Eichler, E.; Bundle, D. R. “Preparation of a Pentasaccharide Antigen for the Investigation of Carbohydrate-Protein Interactions” J. Org. Chem. 1995, 60, 7316-7327.
- Peters, S.; Lowary, T. L.; Hindsgaul, O.; Meldal, M.; Bock, K. “Solid Phase Synthesis of a Fucosylated Glycopeptide of Human Factor IX with a Fucose-alpha-(1,O)-Serine Linkage” J. Chem. Soc. Perkin Trans. 1 1995, 3017-3022.
1994
- Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic O-methyl, Epimeric and Amino Analogs of the Acceptor alpha-L-Fucp-(1,2)-beta-D-Galp-OR by the Blood-Group A and B Gene-Specified Glycosyltransferases” Carbohydr. Res. 1994, 251, 33-67.
- Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic Analogs of the Acceptor beta-D-Galp-OR by the Blood-Group H Gene-Specified Glycosyltransferase” Carbohydr. Res. 1994, 256, 257-273.
- Lowary, T. L.; Bundle, D. R. “Nucleophile Induced Rearrangements of Thioglycosides: Formation of 6-Thio Glycosides and 1,6 Thioanhydrosugars” Tetrahedron:Asymmetry 1994, 12, 2397-2404.
1993
- Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic Deoxy and Deoxyfluoro Analogs of the Acceptor alpha-L-Fucp-(1,2)- beta-D-Galp-OR by the Blood-Group A and B Gene-Specified Glycosyltransferases” Carbohydr. Res. 1993, 249, 163-195.
1991
- Lowary, T. L.; Richards, G. N. “Cycloheptaamylose as a Model for Starch in the Pyrolysis of Polysaccharides” Carbohydr. Res. 1991, 218, 157-166.
1990
- Lowary, T. L.; Richards, G. N. “Mechanisms of Pyrolysis of Polysaccharides: Cellobiitol as a Model for Cellulose“Carbohydr. Res. 1990, 198, 79-89.
1989
- Lowary, T. L.; Richards, G. N. “Analysis of a Hydroxystilbene Glucoside in Several Softwood Barks” J. Wood Chem. and Tech. 1989, 9, 333-340.
1988
- Lowary, T. L.; Richards, G. N. “Effects of Impurities on the Hydrolysis of Sucrose in Concentrated Aqueous Solution” Int. Sugar J. 1988, 90, 164-167.
- Lowary, T. L.; Richards, G. N. “Vacuum Pyrolysis of Bark from Pinus ponderosa” J. Wood Chem. and Tech. 1988, 8, 393-412