780-492-1861 | 780-492-7705 | tlowary@ualberta.ca



  • Lowary, T. L.; Achkar, J. M. “Tailor Made: New Insights Into Lipoarabinomannan Structure May Improve TB DiagnosisJ. Biol. Chem. 2022, 298, 101678.

  • Yang, S.; Chu, C.–J.; Lowary, T. L.; “De novo synthesis of 3,6-dideoxy sugars Org. Lett. 2022, 24, 5614–5618.

  • Shen, K.; Lowary, T. L. “Synthesis of the Mycobacterium tuberculosis Canetti Lipooligosaccharide II NonasaccharideOrg. Lett. 2022, 24, 6428–6432.

  • Forrester, T. J. B.; Nothof, J. T.; Koizumi, A.; Lowary, T. L.; Whitfield, C.; Kimber, M. S. “The mechanism of the retaining β-Kdo glycosyltransferase WbbB uses two discrete SN2 reactions with an intermediate adduct rearrangement step Nat. Commun. 2022, 13, 6277.

  • Vocadlo, D. J; Lowary, T. L.; Bertozzi, C. R.; Schnaar, R. L.; Esko, J. D. “Chemical Tools for Inhibiting Glycosylation” In Essentials in Glycobiology Fourth Edition, Varki, A.; Cummings, R. D.; Esko, J. D.; Stanley, P; Hart, G. W.; Aebi, M.; Mohnen, D.; Kinoshita, T.; Packer, N. H.; Prestegard, J. H.; Schnarr, R. L.; Seeberger, P. H. Cold Spring Harbor Laboratory Press, 2022, Chapter 55.

  • Speciale, I.; Notaro, A.; Abergel, C.; Lanzetta, R.; Lowary, T. L.; Molinaro, A.; Tonetti, M.; Van Etten, J. L.; De Castro, C. “The Astounding World of Glycans Syntheszied by Giant Viruses”. Chem. Rev. 2022, 122, 15717–15766.

  • Nguyen, L.; McCord, K. A.; Bui, D. T.; Bouwman, K. M.; Kitova, E. N.; Elaish, M.; Kumawat, D.; Daskhan, G. C.; Tomris, I.; Han, L.; Chopra, P.; Yang, T.-J.; Willows, S. D.; Mason, A. L.; Mahal, L.  K.; Lowary, T. L.; West, L. J.; Hsu, S.-T. D.; Hobman, T.; Tompkins, S. M.; Boons, G.-J.; de Vries, R. P., Macauley, M. S.; Klassen, J. S. “Sialic Acid-Dependent Binding and Viral Entry of SARS-CoV-2” Nat. Chem. Biol. 2022, 18, 81–90.

  • Kim, T.; Bell, M. R.; Thota, V. N.; Lowary, T. L. “One-pot regioselective diacylation of pyranoside 1,2-cis diols J. Org. Chem. 2022, 87, 4894–4907.

  • Kelly, S. D.; Williams, D. M.; Nothof, J. T.; Kim, T.; Lowary, T. L.; Kimber, M. S.; Whitfield, C.; “The biosynthetic origin of ribofuranose in bacterial polysaccharides”, Nat. Chem. Biol. 2022, 18, 530–537.


  • Angala, S. K.; Joe, M.; McNeil, M. R.; Lowary, T. L.; Liav, A.; Jackson, M. “Use of synthetic glycolipids to probe the number and position of arabinan chains on mycobacterial arabinogalactanACS Chem. Biol. 2021, 16, 20–26.


  • Liang, X.-Y.; Yang, J.; Qiu, Z.-H.; Wang, L.; Lowary, T. L.; Fan, H.-J. S. “A 4,6-di-O-benzylidene-directed preparation of 2-deoxy-2-azido-α-D-galactopyranosides promoted by a 3-O-t-butyldimethylsilyl ether.Carbohydr. Res. 2021, 500, 108237.


  • Sojitra, M.; Sarkar, S.; Maghera, J.; Rodrigues, E.; Carpenter, E.; Seth, S.; Ferrer Vinals, D.; Bennett, N.; Reddy, R.; Khalil, A.; Xue, X.; Bell, M.; Zheng, R. B.; Ling, C.-C.; Lowary, T. L.; Paulson, J. C.; Macauley, M. S.; Derda, R. “Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage Nat. Chem. Biol. 2021, 17, 806–816.
  • Tcheng, M.; Cunha, V. L. S.; Ahmed, N.; Liu, X.; Smith, R. W.; Rea, K. A.; Akhtar, T. A.; D’Alessandro, A.; Vockley, J.; O’Doherty, G. A.; Lowary, T. L.; Spagnuolo, P. A. “Structure–activity relationship of avocadyne” Food & Function, 2021, 12, 6323–6333.


  • Wang, L.; Lowary, T. L. Synthesis of Structurally-Defined Polymeric Glycosylated Phosphoprenols as Potential Lipopolysaccharide Biosynthetic Probes” Chem. Sci. 2021, 12, 12192–12200.


  • Ishida, E.; Corrigan, D. T.; Malonis, R. J.; Hofmann, D.; Chen, T.; Amin, A. G.; Chatterjee, D.; Joe, M.; Lowary, T. L.; Lai, J. R.; Achkar, J. M. “Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes Commun. Biol. 2021, 4, 1181.


  • Bentall, A.; Jeyakanthan, M.; Braitch, M.; Cairo, C. W.; Lowary, T. L.; Maier, S.; Motyka, B.; West, L. J.; Zou, L.; Ball, S. “Characterization of ABH-subtype donor-specific antibodies in ABO-A-incompatible kidney transplantation Am. J. Transplant. 2021, 21, 3649–3662.


  • Anso, I.; Basso, L. G. M.; Wang, L.; Marina, A.; Páez-Pérez, E. D.; Jäger, C.; Gavotto, F.; Tersa, M; Perrone, S.; Contreras, F.-X.; Prandi, J.; Gilleron, M.; Linster, C. L.; Corzana, F.; Lowary, T. L.; Trastoy*, B.; Guerin*, M. E. “Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatASci. Adv. 2021, 7, eabj4565.


  • Shen, K.; Bai, B.; Liu, Y.-H.; Lowary, T. L. “Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii” Angew. Chem. Intl. Ed. 2021, 60, 24859–24863.


  • Han, L.; Xue, X.; Roy, R.; Kitova, E. N.; St-Pierre, Y.; Lowary, T. L. “Neoglycolipids as Glycosphingolipid Surrogates for Protein Binding Studies Using Nanodiscs and Native Mass Spectrometry” Anal. Chem. 2020, 92, 14189–14196.

  • Broger, T.; Nicol, M. P.; Sigal, G. B.; Gotuzzo, E.; Zimmer, A. J. Surtie, S.; Caceres-Nakiche, T.; Mantsoki, A.; Reipold, E. I.; Székely, R.; Tsionsky, M.; Plisova, T.; Chikamatsu, K.; Lowary, T. L.; Pinter, A.; Mitarai, S.; Moreau, E.; Schumacher, S. G.; Dekinger, C. M. “Diagnostic accuracy of 3 urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients” J. Clin. Invest. 2020, 130, 5756–5764.

  • Speciale, I.; Laugieri, M. W.; Noel, E.; Lin, S.; Lowary, T. L.; Molinaro, A.; Duncan, G. D.; Agarkova, I. V.; Garozzo, D.; Tonetti, M. G.; Van Etten, J. L.; De Castro, C. “Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans” Proc. Natl. Acad. Sci. U.S.A., 2020, 117, 28735–28742.

  • Huang, B.-S.; Lowary, T. L. “A Siloxane-Bridged Glycosyl Donor Enables Highly Stereoselective -Xylulofuranosylation” J. Org. Chem. 2020, 85, 15895–15907.

  • Wang. L.; Lowary, T. L. “Synthesis of Rhamnolipid Derivatives Containing Ester Isosteres” Org. Lett. 2020, 22, 9633–9637.

  • Clarke, B. R.; Ovchinnikova, O. G.; Sweeney, R. P.; Kamski-Hennekam, E.; Gitalis, R.; Mallette, E.; Lowary, T. L. Kelly, S. D.; Kimber, M. S.; Whitfield, C. “A bifunctional O-antigen polymerase structure reveals a new family of galactofuranosyltransferases”  Chem. Biol.202016, 450–457.

  • Shen, L.; Viljoen, A.; Villaume, S.; Joe, M.; Chêne, L.; Méry, A.; Fabre, E.; Takegawa, K.; Lowary, T. L.; Vincent, S. P.; Kremer, L.; Guérardel, Y.; Mariller, C. “GlfH1, an endogenous remodeling galactofuranosidase that hydrolyzes mycobacterial arabinogalactan”  Biol. Chem. 2020295, 5110–5123.

  • Chen, T.; Blanc, C.; Liu, Y.; Ishida, E.; Xu, J.; Joe, M.; Jenny-Avital, E. R.; Chan, J.; Lowary, T. L.; Achkar, J. “Importance of capsular glycan recognition in human antibody-mediated immunity against Mycobacterium tuberculosis Clin. Invest. 2020130, 1808–1822.

  • Huang, B.-S.; Lowary, T. L. “β-Selective Xylulofuranosylation Via a Conformationally-Restricted Glycosyl Donor Biomol. Chem. 20208, 2264–2273.

  • Tan, Y. Z.; Zhang, L.; Rodrigues, J.; Zheng, R. B.; Giacometti, S. I.; Rosario, A. L. Kloss, B.; Dandey, V. P.; Wei, H.; Brunton, R.; Raczkowski, A. M.; Athayde, D.; Catalão, M. J.; Pimentel, M.; Clarke, O. B.; Lowary, T. L.; Archer, M.; Niederweis, M.; Potter, C. S.; Carragher, B.; Mancia, F. “Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria”  Cell 2020,78, 683–699.

  • Tan, Y. Z.; Rodrigues, J.; Keener, J. E.; Zheng, R. B.; Brunton, R.; Kloss, B.; Giacometti, S. I.; Rosário, A. L.; Zhang, L.; Niederweis, M.; Clarke, O. B.; Lowary, T. L.; Marty, M. T.; Archer, M.; Potter, C. S.; Carragher, B.; Mancia, F. “Cryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis” Nat. Comm. 202011, 3396.

  • Lin, S.; Lowary, T. L. “Synthesis of a Highly Branched Nonasaccharide Chlorella Virus N-Glycan using a “Counter-Clockwise” Assembly Approach”  Lett. 2020, 22, 7645–7649.


  • Doyle, L.; Ovchinnikova, O. G.; Myler, K.; Mallette, E.; Huang, B.-S.; Lowary, T. L.; Kimber, M. S.; Whitfield, C. “Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules” Nat. Chem. Biol. 2019, 15, 632–640.
  • Palcekova, Z.; Angala, S. K.; Belardinelli, J. M.; Eskandarian, H. A.; Joe, M.; Brunton, R.; Rithner, C.; Jones, V.; Nigou, J.; Lowary, T. L. Gilleron, M.; McNeil, M. R.; Jackson, M. “Disruption of the SucT acyltransferase in Mycobacterium smegmatis abrogates succinylation of cell envelope polysaccharides” J. Biol. Chem. 2019, 294, 10325–10335.
  • Kelly, S. D.; Clarke, B. R.; Ovchinnikova, O. G.; Sweeney, R. P.; Williamson, M. L.; Lowary, T. L.; Whitfield, C. “Klebsiella pneumoniae O1 and O2ac antigens provide prototypes for an unusual strategy for diversification of polysaccharide antigens” J. Biol. Chem. 2019, 294, 10863–10876.
  • Broger, T.; Sossen, B.; du Toit, E.; Kerkhoff, A. D.; Schutz, C.; Reipold, E. I.; Ward, A.; Barr, D. A.; Macé, A.; Trollip, A.; Burton, R.; Ongarello, S.; Pinter, A.; Lowary. T. L.; Boehme, C.; Nicol, M. P.; Meintjes, G.; Denkinger, C. “Novel high sensitivity tuberculosis point-of-care test for people living with HIV” Lancet Infect. Dis. 2019, 19, 852–861.
  • Cunha, V. S.; Liu, X.; Lowary, T. L.; O’Doherty, G. A. “De Novo Asymmetric Synthesis of Avocadyne, Avocadene and Avocadane Stereoisomers”. J. Org, Chem. 2019, 84, 15718–15725.
  • Angala, S. K.; Li, W.; Palčeková, Z.; Zou, L.; Lowary, T. L.; McNeil, M. R. Jackson, M. “Cloning and partial characterization of an endo-α-(1→6)-D-mannanase gene from Bacillus circulans”. Int. J. Mol. Sci. 2019, 20, 6244.
  • Sweeney, R. P.; Lowary, T. L. “New Insights into Lipopolysaccharide Assembly and Export” Curr. Opin. Chem. Biol. 2019, 53, 37–43.
  • Sweeney, R. P.; Lowary, T. L. “A Route to Polyprenol Pyrophosphate-Based Probes of O-Polysaccharide Biosynthesis in Klebsiella pneumoniae O2a” Org Lett. 2019, 21, 1050–1053.
  • Gao, Z.; Ovchinnikova, O. G.; Huang, B.-S.; Liu, F.; Williams, D. E.; Andersen, R. J.; Lowary, T. L.; Whitfield, C.; Withers S. G. “A High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors” J. Am. Chem. Soc. 2019, 141, 2201–2204.
  • Speciale, I.; Duncan, G. A.; Unione, L.; Agarkova, I. V.; Garozzo, D.; Jimenez-Barbero, J.; Lin, S.; Lowary, T. L.; Molinaro, A.; Noel, E.; Laugieri, E.; Tonetti, M.; Van Etten, J. L; De Castro, C. “New Glycan Structures of Chlorovirus PBCV-1 Major Capsid Protein: Antigenic Variants Help Identify Virus-Encoded Glycosyltransferases” J. Biol. Chem. 2019, 294, 5688–5699.
  • Tsionksy; M.; Mathew; A.; Lowary; T. L.; Pinter; A.; Plisova; T.; Bartlett; D.; Barbero, S.; Denkinger. C. M.; Moreau, E.; Katsuragi, K.; Kawasaki; M.; Nahid; P.; Sigal, G. B.; Broger, T. “Sensitive Electrochemiluminescence (ECL) Immunoassays for Detecting Lipoarabinomannan (LAM) and ESAT-6 in Urine and Serum from Tuberculosis Patients” PLOS One. 2019, 14, e0215443.
  • Aboussafy, C. L.; Andersen Gersby, L. B.; Molinaro, A.; Newman, M.-A.; Lowary, T. L. “A Convergent Route to Enantiomers of the Bicyclic Monosaccharide Bradyrhizose Leads to Insight into the Bioactivity of an Immunologically Silent Lipopolysaccharide” J. Org. Chem. 2019, 84, 14–41.


  • Ati, J.; Colas, C.; Lafite, P.; Zheng, R. B.; Sweeney, R. P.; Lowary, T. L.; Daniellou, R. “The LGP1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties” Sci. Rep. 2018, 8, 17566.
  • Sigal, G. B.; Pinter, A.; Lowary, T. L.; Kawasaki, M.; Li, A.; Mathew A.; Tsionsky, M.; Zheng, R. B.; Plisova, T.; Shen, K.; Katsuragi, K.; Choudhary, A.; Honnen, W. J.; Nahid, P.; Denkinger, C. M.; Broger, T. “A novel sensitive immunoassay targeting the MTX-Lipoarabinomannan epitope meets the WHO’s performance target for Tuberculosis diagnosis” J. Clin. Microbiol. 2018, 56, e01338–18.
  • Lin, S.; Lowary, T. L. “Synthesis of the highly branched hexasaccharide core of chlorella virus N-linked glycans” Chem Eur J. 2018, 57, 16992–16996.
  • Thota, V. N.; Ferguson, M. J.; Sweeney, R. P.; Lowary, T. L. “Synthesis of the Campylobacter jejuni 81-176 strain capsular polysaccharide repeating unit reveals the absolute configuration of its O-methyl phosphoramidate motif” Angew. Chem. Intl. Ed. 2018, 57, 15592–15596.
  • Zhang, L.; Shen, K.; Taha, H. A.; Lowary, T. L. “Stereocontrolled synthesis of alpha-xylofuranosides using a conformationally-restricted donor” J. Org. Chem. 2018, 83, 7659–7671.
  • Amin, A. G.; De, P.; Spencer, J. S.; Brennan, P. J.; Daum, J.; Andre, B. G.; Joe, M.; Bai, Y.; Laurentius, L.; Porter, M.; Honnen, W. J.; Choudhary, A.; Lowary, T. L.; Pinter, A.; Chatterjee*, D. “Detection of Lipoarabinomannan in Urine and Serum of HIV-positive and HIV-negative TB Suspects using an improved Capture-Enzyme Linked Immuno Absorbent Assay and Gas Chromatography/Mass Spectrometry” Tuberculosis 2018, 111, 178–187.
  • Jankute, M.; Alderwick, L. J.; Moorey, A. R.; Gurcha, S. S.; Eggeling, L.; Lowary, T. L.; Dell, A.; Pang, P-C.; Yang, T.; Haslam, S.; Besra, G. S. “The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the alpha-(1-5) arabinan backbone in the early stages of cell wall arabinan biosynthesis” Cell Surf. 2018, 2, 38–53.
  • Chou, Y.; Kitova, E.; Joe, M.; Brunton, R. M.; Lowary, T. L.; Klassen, J. S; Derda, R. “Genetically-encoded fragment-based discovery (GE-FBD) of glycopeptide ligands for antibodies related to mycobacterial infections” Org. Biomol. Chem. 2018, 223–227.
  • Daksan, G. C.; Tran, H-T.; Meloncelli, P. J.; Lowary, T. L.; West, L. J.; Cairo, C. W. Construction of multivalent homo- and hetero-functional ABO blood group glycoconjugates using a trifunctional linker strategy” Bioconjugate Chem. 201829, 343–362.
  • Xue, X.; Zhang, R. B.; Koizumi, A.; Han, L.; Klassen, J. S.; Lowary, T. L. “Synthetic Polyprenol-Pyrophosphate Linked Oligosaccharides Are Efficient Substrates for Mycobacterial Galactan Biosynthetic Enzymes Org. Biomol. Chem. 201816, 1939–1957.
  • Cocaud, C.; Zheng, B.; Lowary, T. L; Poisson, T.; Pannecoucke, X.; Nicolas, C.; Martin, O. R. “1-C-Phosphonomethylene- and 1-C-Difluorophosphonomethylene-1,4-imino-l-arabinitols as Galactofuranosyltransferase Inhibitors: A Comparison” Carbohydr. Res. 2018461, 45­–50.
  • Clarke, B. R.; Ovchinnikova, O. G.; Kelly, S. D.; Williamson, M. L.; Butler, J. E.; Liu, B.; Wang, L.; Gou, X.; Follador, R.; Lowary, T. L.; Whitfield, C. “Molecular basis for structural diversity in serogroup O2-antigen polysaccharides in Klebsiella pneumoniae” J. Biol. Chem. 2018293, 4666­–4679.
  • Yang, D.-M.; Chen, Y.; Sweeney, R.; Lowary, T.; Liang, X. “Stereocontrolled Synthesis of 2-Deoxy-Galactopyranosides via Isopropylidene-Protected 6-O-Silylated Donors” Org. Lett. 201820, 2287–2290.
  • Choudhary, A.; Patel, D.; Honnen, W.; Lai, Z.; Prattipati, R.; Zheng, R. B.; Hsueh, Y-C.; Gennaro, M. L.; Lardizabal, A.; Joe, M.; Bai. Y.; Shen, K.; Spencer, J.; Chatterjee, D.; Broger, T.; Lowary, T. L.; Pinter, A. “Characterization of the antigenic heterogeneity of lipoarabinomannan (LAM), the major surface glycolipid of Mycobacterium tuberculosis, and complexity of the humoral immune response towards this antigen” J. Immunol. 2018, 200, 3053­–3066.


  • Prados-Rosales*, R.; Carreño, L.; Weinrick, B.; Lowary, T. L.; Baena, A.; Joe, M.; Bai, Y.; Chow, S.-K.; Kalscheuer, R.; Batista-Gonzalez, A.; Saavedra, N. A.; Chen, T.; Blanc, C.; Xu, J.; Jacobs Jr., W. R.; Chan, J.; Porcelli, S. A.; Achkar, J. M. Casadevall, A. “Arabinomannan-protein conjugates induce a protective response in mice that controls Mycobacterium tuberculosis dissemination” PLoS Pathogens2017, 13, e1006250.
  • Angala, S. K; McNeil, M. R.; Shi, L.; Pham, H.; Zuberogoitia, S.; Nigou, J.; Boot, C. M.; Lowary, T. L.; Gilleron, M.; Jackson, M. “Biosynthesis of the methylthioxylose capping motif of lipoarabinomannan in Mycobacterium tuberculosis” ACS Chem. Biol. 2017, 12, 682–691.
  • Williams, D. M.; Ovchinnikova, O. G.; Koizumi, A.; Mainprize, I. L.; Kimber, M. S.; Lowary, T. L.; Whitfield, C.  “A single polysaccharide assembly protein that integrates polymerization, termination and chain-length quality control” Proc. Natl. Acad. Sci. U.S.A.2017, 114, E1215–E1223.
  • Fiege, B.; Leuthold, M.; Parra, F.; Dalton, K. P.; Meloncelli, P. J.; Lowary, T. L. Peters, T. “Epitope mapping of histo blood group antigens bound to norovirus VLPs using STD NMR experiments reveals fine details of molecular recognition” Glycoconjug. J. 201734, 679–689.
  • Cocaud, C.; Maujoin, A.; Rodrigues, N.; Zheng, R. B.; Buron, F.; Routier, S.; Lowary, T. L.; Nicolas, C.; Martin, O. R. “Triazole-Linked Iminosugars and Aromatic Systems as Simplified UDP-Galf Mimics: Synthesis and Preliminary Evaluation as Galf-transferase Inhibitors” Eur. J. Org. Chem2017, 6192–6201.
  • Zheng, R.B.; Jégouzo, S. A. F.; Joe, M.; Bai, Y.; Tran, H. A.; Shen, K.; Saupe, J.; Xia, ; Ahmed, M. F.; Liu, Y.-H.; Patil, P. S.; Tripathi, A.; Hung, S.-C.; Taylor*, M. E.; Lowary, T. L.; Drickamer*, K. “Insights into mycobacteria interactions with the host innate immune system from a novel array of synthetic mycobacterial glycans.” ACS Chem. Biol. 201712, 2990–3002.


  • Poulin, M. B.; Lowary, T. L. “Chemical Insight Into the Mechanism and Specificity of GlfT2, a Bifunctional Galactofuranosyltransferase from Mycobacteria” J. Org. Chem. 2016, 81, 8123–8130.
  • Lowary, T. L. “Twenty Years of Mycobacterial Glycans. Furanosides and Beyond.” Acc. Chem. Res. 2016, 49, 1379–1388.
  • Joe, M.; Lowary, T. L. “Synthesis of a homologous series of galactofuranose-containing mycobacterial arabinogalactan fragments” Can. J. Chem. 2016, 94, 976–988.
  • Frédéric, C.; Tikad, A.; Jian, F.; Pan, W.; Zheng, R. B.; Koizumi, A.; Xue, X.; Lowary, T. L.; Vincent, S P. “Synthesis of unprecedented sulfonylated phosphono-exo-glycals designed as inhibitors of the three mycobacterial galactofuranose processing enzymes” Chem. Eur. J. 2016, 22, 15913–15920.
  • Ovchinnikova, O. G.; Doyle, L.; Huang, B.-S.; Kimber, M. S.; Lowary, T. L.; Whitfield, C. “Biochemical characterization of bifunctional 3-deoxy-β-D-manno-oct-2-ulosonic acid (β Kdo) transferase KpsC from Escherichia coli involved in capsule biosynthesis” J. Biol. Chem. 2016, 291, 21519–21530.
  • Liu, L.; Siuda, I.; Richards, M. R.; Renaud, J.; Kitova, E. N.; Mayer, P. M.; Tieleman, D. P.; Lowary, T. L.; Klassen, J. S. “Structure and Stability of Carbohydrate–Lipid Complexes” ChemBioChem 2016, 17, 1571–1578.
  • Li, J., Lowary, T. L. “Synthesis and evaluation of bicyclo[3.1.0]hexane-based UDP-Galf analogues as inhibitors of the mycobacterial galactofuranosyltransferase GlfT2” Molecules 2016, 21, 1053.
  • Harrison, J.; Lloyd, G.; Joe, M.; Lowary, T. L. Reynolds, E.; Walters-Morgan, H.; Bhatt, A.; Lovering, A. L.; Besra, G. S.; Alderwick, L. J. “PagL is a phosphotransferase responsible for ligating arabinogalactan to peptidoglycan in Mycobacterium tuberculosis” mBio2016, 7, e00972-16.
  • Chen, T.; Blanc, C.; Eder, A. Z.; Prados-Rosales, R.; Oliveira-Souza, A. C.; Kim, R. S.; Joe, M.; Bai, Y.; Lowary, T. L.; Tanner, R.; Brennan, M. J.; Fletcher, H. A.; McShane, H.; Casadevall, A.; Achkar, J. M. “Association of Human Antibodies to Arabinomannan with Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction” J. Infect. Dis. 2016, 214, 300–310.
  • Lin, S.; Ashmus, R. A.; Lowary, T. L. “An oxidation–amidation approach for the synthesis of glycuronamides” Eur. J. Org. Chem. 2016, 2653–2644.
  • Angala, S. K.; McNeil, M. R.; Zou, L.; Liav, A.; Zhang, J.; Lowary, T. L.; Jackson, M. “Identification of a novel mycobacterial arabinosyltransferase activity which adds an arabinosyl residue to α-D-mannosyl residues” ACS Chem. Biol. 2016, 11, 1518–1524.
  • Ovchinnikova, O. G.; Mallette, E.; Koizumi, A.; Lowary, T. L.; Kimber*, M. S.; Whitfield, C. “The structure and function of a prototype bacterial β-Kdo glycosyltransferase reveals a new glycosyltransferase family” Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E3120–E3129.
  • Jeyakanthan, M.; Meloncelli, P. J.; Zou, L.; Lowary, T. L.; Larsen, I.; Maier, S; Tao, K.; Rusch, J.; Chinnock, R.; Shaw, N.; Burch, M.; Beddows, K.; Addonizio, L.; Zuckerman, W.; Pahl, E.; Rutledge, J.; Kanter, K. R. Cairo, C. W.; Buriak, J. M.; Ross, D.; Rebeyka, I.; West, L. J. “ABH-glycan microarray characterizes ABO subtype antibodies: fine specificity of immune tolerance after ABO-incompatible transplantation” Am. J. Transplant. 2016, 16, 1548–1558.
  • Ashmus, R. A.; Jayasuriya, A. B.; Lim, Y. J.; O’Doherty, G. A. Lowary, T. L. “De novo asymmetric synthesis of a 6-O-methyl-D-glycero-L-gluco-heptopyranose-derived thioglycoside for the preparation of Campylobacter jejuni NCTC11168 capsular polysaccharide fragments” J. Org. Chem. 2016, 81, 3058–3063.
  • Slaney, A.; Dijke, I. E.; Jeyakanthan, M.; Li, C.; Zou, L.; Plaza-Alexander, P. M.; Meloncelli, P. J.; Bau, J.; Allan, L.; Lowary, T.L.; West, L. J.; Cairo, C. W.; Buriak*, J. M. “Conjugation of A and B Blood Group Structures to Silica Microparticles for the Detection of Antigen-Specific B Cells” Bioconjug. Chem.2016, 27, 705–715.
  • Schieck, E.; Lartigue, C.; Frey, J.; Vozza, N.; Miller, R.; Nene, V.; Muriuki, C.; Naessens, J.; Lowary, T. L.; Vashee, S.; Feldman, M. F.; Jores*, J. “Genome editing of Mycoplasma mycoides via genome transplantation and mutagenesis in yeast provides insights into the functional role of UDP-galactopyranose mutase and capsular galactan” Mol.Microbiol. 201699, 55–70.


  • Jeyakanthan, M.; Tao, K. S.; Zou, L.; Meloncelli, P. J.; Lowary, T. L.; Suzuki, K., Boland, D.; Larson, I.;  Burch, M.; Shaw, N.; Beddows, K.; Addonizio, L.; Zuckerman, W.; Afzali, B.; Kim, D. H.; Mengel, A. M.; Shapiro, A. M. J.; Burch, M.; West, L. J. “Chemical basis for qualitative and quantative differences between ABO blood groups: implications for organ transplantation” Am. J. Transplant. 201515, 2602–2615.
  • Gagnon, S. M. L.; Meloncelli, P. J.; Zheng, R. B.; Haji-Ghassemi, O.; Johal, A. R.; Borisova, S.; Lowary, T. L.; Evans, S. V. “High resolution structures of the human ABO(H) blood group enzymes in complex with donor analogs reveal that the enzymes utilize multiple donor conformations to bind substrates in a step-wise manner” J. Biol. Chem. 2015290, 428–437.
  • Sahloul, K.; Lowary, T. L. “Development of an Orthagonal Protection Startegy for the Synthesis of Mycobacterial Arabinomannan Fragments” J. Org. Chem. 201580, 11417-11434.
  • Poopari, M. R.; Dezhahang, Z.; Shen, K.; Wang, L.; Lowary, T. L.; Xu, Y. “Absolute Configuration and Conformation of Two Fráter–Seebach Alkylation Reaction Products by Film VCD and ECD Spectroscopic Analyses” J. Org. Chem. 201580, 428–437.
  • Zhang, D.; Huang, P.; Zou, L.; Lowary, T. L.; Tan, M.; Jiang X. “Tulane virus recognizes the A-type III and B histo-blood group antigens” J. Virol. 201589, 1419–1427.
  • Lak, P.; Makeneni, S.; Woods, R. J.; Lowary, T. L. “Specificity of Furanoside–Protein Recognition through Antibody Engineering and Molecular Modeling” Chem. Eur. J. 201521, 1138–1148.
  • Liston, S. D.; Clarke, B. R.; Greenfield, L. K.; Richards, M. R.; Lowary, T. L.; Whitfield, C. “Domain interactions control complex formation and polymerase specificity in the biosynthesis of the Escherichia coli O9a antigen” J. Biol. Chem. 2015290, 1075–1085.
  • Wang L.; Dong, M.; Lowary, T. L. “Synthesis of Unusual N-Acylated Aminosugar Fragments of Mycobacterium marinum Lipooligosaccharide IV” J. Org. Chem. 201580, 2767–2780.
  • Elsaidi, H. R. H.; Lowary, T. L. “Effect of phenolic glycolipids from Mycobacterium kansasii on proinflammatory cytokine release. A structure–activity relationship study” Chem. Sci.20156, 3161–3172.
  • Conde, P.; Rodriguez, M.; van der Touw, W.; Jimenez, A.; Burns, M.; Miller, J.; Brahmachary, M.; Chen, H.-M.; Boros, P.; Rausell-Palamos, F.; Yun, T. J.; Riquelme, P.; Rastrojo, A.; Aguado, B.; Stein-Streilein, J.; Tanaka, M.; Zhou, L.; Zhang, J.; Lowary, T. L.; Ginhoux, F.; Park, C. G.; Cheolho, C.; Brody, J.; Turley, S.; Lira, S.; Bronte, V.; Gordon, S.; Heeger, P.; Merad, M.; Hutchinson, J.; Chen, S- H.; Ochando, J. “DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance” Immunity201542, 1143–1158.
  • Bai, B.; Chu, C.-J.; Lowary, T. L. “Lipooligosaccharides from Mycobacteria. Structure, Function and Synthesis” Isr. J. Chem. 201555, 360–372.


  • Arutyunov, D.; Singh, U.; El-Hawiet, A.; Dos Santos Seckler, H.; Nikjah, S.; Joe, M.; Bai, Y.; Lowary, T. L.; Klassen, J.S.; Evoy*, S.; Szymanski*, C. M. “Application of mycobacteriophage cell binding proteins for the detection of mycobacteria” Bacteriophage 20144, e960346.
  • Backus, K. M.; Dolan, M. A.; Barry, C. S.; Joe, M.; McPhie, P.; Boshoff, H. I. M.; Lowary, T. L.; Davis, B. G.; Barry III; C. E. “The Three Mycobacterium Tuberculosis Antigen 85 Isoforms have Unique Substrates and Activities Determined by Non-active Site Regions” J. Biol. Chem. 2014289, 25041-25053.
  • Zhai, Y.; Dasog, M.; Snitynski, R. B.; Purkait, T. K.; Aghajamali, M.; Hahn, A. H.; Sturdy, C. B.; Lowary, T. L.; Veinot, J. G. C. “Water-soluble Photoluminescent D-Mannose and L-Alanine Functionalized Silicon Nanocrystals and Their Application to Cancer Cell Imaging” J. Mater. Chem. 20142, 8427-8433.
  • Ashmus, R. A.; Lowary, T. L. “Synthesis of Carbohydrate Methyl Phosphoramidates” Org. Lett. 201416, 2518-2521.
  • Elsaidi, H. R. H.; Lowary, T. L. “Inhibition of Cytokine Release by Mycobacterium tuberculosis Phenolic Glycolipid Analogs” ChemBioChem 201415, 1176-1182.
  • Li, J.; Lowary, T. L. “Sulfonium Ions as Inhibitors of the Mycobacterial Galactofuranosyltranserase GlfT2” Med. Chem. Comm. 20145, 1130-1137.
  • van Alphen, L.; Wenzel, C. Q.; Richards, M. R.; Fodor, C.; Ashmus, R. A.; Stahl, M.; Karlyshev, A. V.; Wren, B. W.; Stintzi, A.; Miller, W. G.; Lowary, T. L.; Szymanski, C. M. “Biological roles of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni” PLoS ONE 20149, e87051.
  • Poulin, M. B.; Shi, Y.; Protsko, C.; Dalrymple, Sanders, D. A. R.; Pinto, B. M.; Lowary, T. L. “Specificity of a UDP-GalNAc pyranose-furanose mutase. A potential therapeutic target for Campylobacter jejuni infections” ChemBioChem 201415, 47-56.
  • Snitynsky, R. B.; Lowary, T. L. “Synthesis of nitrogen-containing furanose sugar nucleotides for the use as enzymatic probes” Org. Lett. 2014,16, 212-215.


  • Lowary, T. L. “Context and Complexity: The Next Big Thing in Synthetic Glycobiology” 201317, 990-996.
  • Zhang, J.; Zou, L.; Lowary, T. L. “Synthesis of the tolerance inducing oligosaccharide lacto-N-fucopentaose III bearing an activated linker” ChemistryOpen20132, 156-163.
  • Elsaidi, H. R. Barreda, D. R.; Cairo, C. W.; Lowary, T. L. “Simplified mycobacterial phenolic glycolipid analogs modulate cytokine levels via Toll-Like receptor 2” ChemBioChem 201314, 2153-2159.
  • Xia, L.; Lowary, T. L. “Amphiphilic cytosolic glycans from mycobacteria. Occurence, lipid-binding properties, biosynthesis and synthesis” Biopolymers 201399, 697-712.
  • Ahmed, M. F.; Lowary, T. L. “Glycosylations with 2,3-Aziridinofuranose Derivatives” Tetrahedron 201369, 4276-4284.
  • Richards, M. R.; Bai, Y.; Lowary, T. L. “Comparison between DFT- and NMR-based conformational analysis of methyl galactofuranosides” Carbohydr. Res. 2013374, 103-114.
  • Willis, L. M.; Stupak, J.; Richards, M. R.; Li, J.; Lowary, T. L.; Whitfield*, C. “Structure of a conserved glycolipid terminus for capsular polysaccharides synthesized by the ABC transporter-dependent pathway in Gram-negative pathogens” Proc. Natl. Acad. Sci. U.S.A. 2013110, 7868-7873.
  • Taha, H. A.; Richards, M. R.; Lowary, T. L. “Conformational Analysis of Furanoside-Containing Mono- and Oligosaccharides” Chem. Rev. 2013113, 1851-1876.
  • Xia, L.; Lowary, T. L. “Regioselective Polymethylation of α-(1-4)-linked Mannopyranose Oligosaccharides” J. Org. Chem. 201378, 2863-2880.
  • Plaza-Alexander, P.; Lowary T. L. “Synthesis of trisaccharides incorporating the α-Gal antigen functionalized for neoglycoconjugate preparation” ARKIVOC 2013, ii, 112-122. Invited contribution to special issue in tribute to Professor Richard R. Schmidt.


  • Peng, W.; Zou, L.; Bhamidi, S.; McNeil, M. R.; Lowary T. L. “The galactosamine residue in mycobacterial arabinogalactan is α-linked” J. Org. Chem. 201277, 9826-9832.
  • Greenfield, L. K.; Richards, M. R.; Vinogradov, E.; Wakarchuk, W. W.; Lowary T. L.; Whitfield, C. “Domain Organization of the Polymerizing Mannosyltransferases Involved in Synthesis of the Escherichia coli O8 and O9a Lipopolysaccharide O Antigens” J. Biol. Chem. 2012287, 38135-38149.
  • Liu, L.; Bai, Y.; Sun, N.; Xia, L.; Lowary T. L.; Klassen, J. S. “Carbohydrate-Lipid Interactions. Affinities of Methylmannose Polysaccharides for Lipids in Aqueous Solution” Chem. Eur. J. 201218, 12059-12067.
  • Greenfield, L. K.; Richards, M. R.; Li, J.; Wakarchuk, W. W.; Lowary T. L. “Biosynthesis of the Polymannose Lipopolysaccharide O Antigens from Escherichia coliSerotypes O8 and O9a Requires a Unique Combination of Mannosyltransferase Modules in Single- and Multi-Active Site Enzymes” J. Biol. Chem. 2012287, 35078-35091.
  • Zou, L.; Zheng, R. B.; Lowary T. L. “Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica.” Beilstein J. Org. Chem. 20128, 1219-1226. Invited contribution to “Synthesis in the Glycosciences” Thematic Issue.
  • Wheatley, R. W.; Zheng, R. B.; Richards, M. R.; Lowary T. L.; Ng, K. K. S. “Tetrameric structure of GlfT2 reveals a scaffold for the assemble of mycobacterial arabinogalactan” J. Biol. Chem. 2012287, 28132-28143.
  • Xia, L; Zheng R. B.; Lowary T. L. “Revisiting the specificity of an α-(1,4)-mannosyltransferase involved in mycobacterial methylmannose polysaccharide biosynthesis” ChemBioChem 201213, 1139-1151.
  • Poulin, M. B.; Zhou, R.; Lowary T. L. “Synthetic UDP-galactofuranose analogs reveal critical enzyme-substrate interactions in GlfT2-catalyzed mycobacterial galactan assembly” Org. Biomol. Chem. 201210, 4074-4087.
  • Sarkar, S.; Tang, X. L.; Das, D.; Lowary, T. L.; Suresh, M. R. “A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings” PLOS One20127, e32340.


  • Clarke, B. R.; Richards, M. R.; Greenfield, L. K.; Hou, D.; Lowary, T. L.; Whitfield, C. In vitro “Reconstruction of the Chain Termination Reaction in Biosynthesis of theEscherichia coli O9a O-polysaccharide; the Chain-length Regulator, WbdD, Catalyzes the Addition of Methyl Phosphate to the Non-reducing Terminus of the Growing Glycan” J. Biol. Chem. 2011286, 41391–41401.
  • Peng, W.; Jayasuriya, A. B.; Imamura, A.; Lowary, T. L. “Synthesis of the 6-O-methyl-D-glycero-α-L-gluco-heptopyranose moiety present in the capsular polysaccharide from Campylobacter jejuni NCTC 11168” Org. Lett. 201113, 5290-5293.
  • Islam, S. M.; Richards, M. R.; Taha, H. A.; Byrns, S. C.; Lowary, T. L.; Roy, P. N. “Conformational analysis of oligoarabinofuranosides: overcoming torsional barriers with umbrella sampling J. Chem. Theor. Comput. 20117, 2989-3000.
  • Higgins, M. A.; Ficko-Blean, E.; Meloncelli, P. J.; Lowary, T. L.; Borastan*, A. B. “The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate Antigen Hydrolyzing Enzymes J. Mol. Biol. 2011411, 1017-1036.
  • Imamura, A.; Lowary, T. L. “Methods for the Chemical Synthesis of Furanose Glycosides” Trends Glycosci. Glycotech. 201123, 134-152.
  • Slaney, A. M.; Wright, V. A.; Meloncelli, P. J.; Harris, K. D.; West, L. J.; Lowary, T. L.; Buriak, J. M. “Biocompatible Carbohydrate-Functionalized Stainless Steel Surfaces: A New Method for Passivating Biomedical Implants” ACS App. Mater. Interfaces. 20113, 1601-1612.
  • Meloncelli, P. J.; West, L. J.; Lowary, T. L. “Synthesis and NMR Studies on the ABO Histo-Blood Group Antigens: Synthesis of Type III and IV Structures and NMR Characterization of Type I–VI Antigens” Carbohydr. Res. 2011346, 1406–1426.
  • Shi, W.; Lowary, T.L. “Effect of Carbohydrate Amino Group Modifications on the Cytotoxicity of Glycosylated 2-Phenyl benzo-β-thiophenes and 2-Phenyl benzo-β-furans” Bioorg. Med. Chem. Lett. 2011, 21, 2591-2596.
  • Shi, W.; Lowary, T.L. “Structure-Activity Relationships in Glycosylated 2-Phenyl-indoles, 2-Phenyl-benzo-β-thiophenes and 2-Phenyl-benzo-β-furans as DNA Binding and Potential Anti-tumor Agents” Bioorg. Med. Chem. 2011, 19, 1779-1789.
  • Taha, H. A.; Roy, P. N. Lowary, T. L. “Theoretical Investigations on the Conformation of the β-Arabinofuranoside Ring” J. Chem. Theory Comput. 2011, 7, 420-432.
  • Harrison, J. A.; Ravindranathan Kartha, K. P.; Fournier, E. J. L.; Lowary, T. L.; Malet, C.; Nilsson, U. J.; Hindsgaul, O.; Schenkman, S.; Naismith, J. H.; Field, R. A. “Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries Org. Biomol. Chem. 2011, 9, 1653-1660.
  • Frigell, J.; Pearcey, J. A.; Lowary, T. L. Cumpstey, I. “Carbasugar analogues of galactofuranosides: Pseudodisaccharide mimics of fragments of mycobacterial arabinogalactan Eur. J. Org. Chem. 2011, 1367-1375.
  • Liu, C.; Richards, M. R.; Lowary, T. L. “Synthesis and NMR Spectroscopic Analysis of Acylated Pentasaccharide Fragments of Mycobacterial Arabinogalactan” Org. Biomol. Chem. 2011, 9, 165–176.
  • Vembaiyan, K.; Pearcey, J. A.; Bhasin, M.; Lowary, T. L.; Zou, W. “Synthesis of sugar–amino acid–nucleosides as potential glycosyltransferase inhibitors” Bioorg. Med. Chem. 2011, 19, 58–66.
  • Shi, W.; Marcus, S. L.; Lowary, T. L. “Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” Bioorg. Med. Chem. 2011, 19, 603–612.


  • Peltier, P.; Beláňová, M.; Dianišková, P.; Brennan, P. J.; Zhou, R.; Zheng, R. B.; Pearcey, J. A.; Joe, M.; Nugier-Chauvin, C.; Ferrières, V.; Lowary, T. L.; Daniellou, R.; Mikušová, K. “Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis” Chem. Biol. 2010, 17, 1267–1366.
  • Meloncelli, P. J.; Lowary, T. L. “Synthesis of ABO Histo-blood Group Type I and II Antigens” Carbohydr. Res. 2010, 345, 2304–2321.
  • Tam, P.-H., Lowary, T. L. Mycobacterial lipoarabinomannan fragments as haptens for potential anti-tuberculosis vaccines” RSC Specialist Periodical Reports, Carbohydrates 2010, 36, 38–58.
  • Poulin, M. B.; Lowary, T. L. “Methods to Study the Biosynthesis of Bacterial Furanosides” Methods Enzymol. 2010, 478, 389–411.
  • Oppenheimer, M.; Poulin, M. B.; Lowary, T. L. Helm, R. R.; Sobrado, P. “Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus” Arch. Biochem. Biophys. 2010, 502, 31–33.
  • Yang, G.; Li, J.; Liu, Y.; Lowary, T. L.; Xu, Y. “Determination of the Absolute Configurations of Bicyclo[3.1.0]hexane Derivatives via Electronic Circular Dichroism, Optical Rotation Dispersion and Vibrational Circular Dichroism Spectroscopy and Density Functional Theory Calculations” Org. Biomol. Chem. 2010, 8, 3777–3783.
  • Imamura, A.; Lowary, T. L. “β-Selective Arabinofuranosylation Using a 2,3-O-Xylylene-protected Donor” Org. Lett. 2010, 12, 3686–3689.
  • Liu, C.; Richards, M. R.; Lowary, T. L. “Probing the Effect of Acylation on Arabinofuranose Ring Conformation in Di- and Trisaccharide Fragments of Mycobacterial Arabinogalactan” J. Org. Chem. 2010, 75, 4992–5007.
  • Szczepina, M. G.; Zheng, R. B.; Completo, G. C.; Lowary, T. L.; Pinto, B. M. “STD-NMR Studies of Two Acceptor Substrates of GlfT2, a Galactofuranosyltransferase from M. tuberculosis: Epitope Mapping Studies” Bioorg. Med. Chem. Lett. 2010, 18, 5123–5125.
  • Yang, G.; Tran, H.; Fan, E.; Shi, W.; Lowary, T. L.; Xu, Y. “Determination of the Absolute Configurations of Synthetic Daunorubicin Analogues Using Vibrational Circular Dichroism Spectroscopy and Density Functional Theory” Chirality, 2010, 22, 734–743.
  • Taha, H. A.; Castillo, N. C.; Sears, D. N. Wasylishen, R. E.: Lowary, T. L. Roy, P.-N. “Conformational analysis of arabinofuranosides: Prediction of 3JH,H using MD Simulations with DFT-derived Spin–Spin Coupling Profiles” J. Chem. Theory Comput. 2010, 6, 212–222.
  • Tam, P.-H.; Lowary, T. L. “Epimeric and amino disaccharide analogs as probes of an alpha-(1,6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis” Org. Biomol. Chem. 2010, 8, 181–192.
  • Poulin, M. B.; Nothaft, H.; Hug, I.; Feldman, M. F. Szymanski, C. M.; Lowary, T. L. “Characterization of a Bifunctional Pyranose–Furanose Mutase from Campylobacter jenuni 11168” J. Biol. Chem. 2010, 285, 493–501.
  • Shi, W.; Marcus, S. L.; Lowary, T. L. “Synthesis and Antibacterial Activity of Aminosugar-Functionalized Intercalating Agents” Carbohydr. Res. 2010, 345, 10–22.




  • Pan, Y.; Lowary, T. L.; Tykwinksi, R.R. “Naturally Occurring and Synthetic Polyyne Glycosides” Can. J. Chem. 2009, 87, 1565–1582.
  • Tam, P.-H., Lowary, T. L. “Recent Advances in Mycobacterial Cell Wall Glycan Biosynthesis” Curr. Opin. Chem. Biol. 2009, 13, 618–625.
  • Szczepina, M. G.; Zheng, R. B.; Completo, G. C.; Lowary, T. L.; Pinto, B. M. “STD-NMR Studies Suggest that Two Acceptor Substrates for GlfT2, a Bifunctional Galactofuranosyltransferase Required for the Biosynthesis of Mycobacterium tuberculosis Arabinogalactan, Compete for the Same Binding Site” ChemBioChem 2009, 10, 2052–2059.
  • Shi, W.; Coleman, R. S. Lowary, T. L. “Synthesis and DNA-Binding Affinity Studies of Glycosylated Intercalators Designed as Functional Mimics of the Anthracycline Antibiotics” Org. Biomol. Chem. 2009, 3709–3722.
  • Murase, T.; Zheng, R. B.; Joe, M.; Bai, Y.; Marcus, S. L.; Lowary, T. L.; Ng, K. K. S. “Structural insights into host recognition of mycobacterial polysaccharides” J. Mol. Biol. 2009, 392, 381–392.
  • Hou, D.; Taha, H. A.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Mechanism of 2-Deoxy-2-Thioaryl Glycoside Formation” J. Am. Chem. Soc. 2009, 131, 12937–12948.
  • Richards, M. R.; Lowary, T. L. “Chemistry and Biology of Galactofuranose-Containing Polysaccharides” ChemBioChem 2009, 10, 1920–1938. Hou, D.; Lowary, T. L. “Recent Advances in the Synthesis of 2-Deoxy-glycosides” Carbohydr. Res. 2009, 344, 1910–1939.
  • Hou, D.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to Furanosyl Azides and C-glycosides” Tetrahedron 2009, 65, 5916–5921.
  • Meloncelli, P. J.; Lowary, T. L. “Synthesis of ABO Type V and VI Antigens” Aust. J. Chem. 2009, 62, 558–574.
  • Meloncelli, P. J.; Martin, A. D.; Lowary, T. L. “Glycosyl iodides. History and recent advances” Carbohydr. Res. 2009, 344, 1110-1122.
  • Carapito, R.; Imberty, A.; Jeltsch, J.-M.; Byrns, S. C.; Tam, P.-H.; Lowary, T. L.; Varrot, A.; Phalip, V. “Molecular basis of arabinobio-hydrolase activity in phytopathogenic fungi. Crystal structure and catalytic mechanism of Fusarium graminearum GH93 α-L-arabinofuranosidase” J. Biol. Chem. 2009, 284, 12285–12296
  • Hou, D.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to 2,6-Dideoxy-pyranosides” J. Org. Chem. 2009, 74, 2278–2289. Selected as a Feature Article by JOC editor.
  • Taha, H. A.; Castillo, N.; Roy, P.-N.;Lowary, T. L.”Conformational Studies of Methyl β-D-Arabinofuranoside Using the AMBER/GLYCAM Approach” J. Chem. Theory Comput. 2009, 5, 430-438.


  • Phillips, R. L.; Kim, I.-K.; Bradley E. Carson, B. E.; Tidbeck, B.; Bai, Y.; Lowary, T. L.; Bunz, U. H. F. “Sugar-substituted poly(para-phenyleneethynylenes) and their interaction with concanavalin A and bacteria” Macromolecules 2008, 41, 7316–7320.
  • Rose, N. L.; Zheng, R. B.; Pearcey, J.; Zhou, R.; Completo, G. C.; Lowary, T. L. “Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase” Carbohydr. Res.2008, 343, 2130–2139.
  • Completo, G. C.; Lowary, T. L. “Synthesis of galactofuranose-containing acceptor substrates for mycobacterial galactofuranosyltransferases” J. Org. Chem. 2008, 73, 4513–4525.
  • Shi, L.; Zhou, R.; Liu, Z.; Lowary, T. L.; Seeberger, P. H.; Stocker, B. L.; Crick, D. C.; Khoo, K.-H.; Chatterjee, D. “Transfer of the first arabinofuranose residue to galactan is essential for mycobacterial viability” J. Bacteriol. 2008, 190, 5248–5255.
  • Birch, H. J.; Alderwick, L. J.; Bhatt, A.; Rittmann, D.; Krumbach, K.; Singh, A.; Bai, Y.; Lowary, T. L. Eggeling, L.; Besra, G. S.“Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha-(1,3) arabinofuranosyltransferase” Mol. Microbiol. 2008, 69, 1191–1206.
  • Hou, F.; Skogman, F.; Lowary, T. L. “Synthesis of 8-azidooctyl glycoside derivatives of the O-chain repeating unit of Escherichia coli O9a lipopolysaccharide and a methylated analogue” Carbohydr. Res. 2008, 343, 1779–1790.
  • Li, J.; Lowary, T. L. “Synthesis of Bicyclo[3.1.0]hexane Derivatives as Conformationally-Restricted Analogues of beta-Arabinofuranosyl and arabino-Galactofuranosyl Rings” Org. Lett. 2008, 10, 881–884.
  • Alfaro, J. A.; Zheng, R. B.; Persson, M.; Letts, J. A.; Polakowski, R.; Bai, Y.; Borisova, S. N.; Seto, N. O. L.; Lowary, T. L.; Palcic, M. M.; Evans, S. V. “ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes” J. Biol. Chem. 2008, 283, 10097–10108.
  • Appelmelk, B. J.; den Dunnen, J.; Ummels, R.; Pak, M.; Larrouy-Maumus, G.; Nigou, J.; Gurcha, S. S.; Movahedzadeh, F.; Brown, E. J.; Eysink Smeets, M. M.; Besra, G. S.; Willemsen, P. T. J.; Lowary, T. L.; van Kooyk, Y.; Maaskant, J. J.; Stoker, N.; Ley, P. v. d.; Puzo, G.; Vandenbroucke-Grauls, C. M. J. E.; Wieland, C. W.; van der Poll, T.; Geijtenbeek, T.; van der Sar, A M.; Bitter. W. “The mannose cap of lipoarabinomannan is not important for mycobacterial virulence.” Cell. Microbiol. 2008, 10, 930–944.
  • Tam, P.-H.; Besra, G. S.; Lowary, T. L. “Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1,6)-mannosyltransferase” ChemBioChem 2008, 267–278.
  • Seo, M.; Castillo, N.; Ganzynkowicz, R.; Daniels, C. R.; Woods, R. J.; Roy, P.-N.; Lowary, T. L. “An approach for the simulation and modeling of flexible rings. Application to the alpha-D-arabinofuranoside ring, a key constituent of polysaccharides from Mycobacterium tuberculosis” J. Chem. Theory Comput. 2008, 4, 184–191.
  • Belánová, M.; Dianišková, P.; Brennan, P. J.; Completo, G. C.; Rose, N. L. Lowary, T. L.; Mikušová, K. “Galactosyl Transferases in Mycobacterial Cell Wall Synthesis” J. Bacteriol. 2008, 190, 1141–1145.


  • Kim, H.-S.; Ng, E. S. M.; Zheng, R. B.; Whittal, R.; Schriemer, D. C.; Lowary, T. L. “Studies Toward the Development of Anti tuberculosis Vaccines Based on Mycobacterial Lipoarabinomannan” ACS Symp. Ser. 2007, 989, 184–197.
  • Liu, C.; Skogman, F.; Cai, Y.; Lowary, T. L. “Synthesis of the ‘primer-adaptor’ trisaccharide moiety of Escherichia coli O8, O9 and O9a lipopolysaccharide” Carbohydr. Res. 2007, 342, 2818–2825.
  • Hou, D.; Lowary, T. L. “Stereoselective synthesis of 2-Deoxy-furanosides from 2,3-Anhydro-furanosyl Thioglycosides” Org. Lett. 2007, 9, 4487–4490.
  • Liu, C.; Skogman, F.; Cai, Y.; Lowary, T. L. “Synthesis of the ‘primer-adaptor’ trisaccharide moiety of Escherichia coli O8, O9 and O9a lipopolysaccharide” Carbohydr. Res. 2007, 342, 2818–2825.
  • Sefzik, T.; Houseknecht, J. B.; Clark, T. M.; Prasad, S.; Lowary, T. L.; Gan, Z.; Grandinetti, P. J. “Solid State 17O-NMR in Carbohydrates” Chem. Phys. Lett. 2007, 434, 312–315.
  • Fan, E.; Shi, W.; Lowary, T. L. “Synthesis of daunorubicin analogs containing truncated aromatic cores and unnatural monosaccharide residues” J. Org. Chem. 2007, 72, 2917–2928.
  • Voehringer, D.; Stanley, S. A.; Cox, J. S.; Lowary, T. L.; Locksley*, R. M. “Identification of Intelectin-1 and -2 as Novel Stat6-dependent Genes Expressed in Lung and Intestine During Helminth Infection” Exp. Parasitol. 2007, 116, 458-466.
  • Tam, P.-H.; Lowary, T. L. “Synthesis of a Panel of Deoxy and Methoxy Analogs of the alpha-Manp-(1,6)-a-Manp-O(CH2)7CH3 Acceptor Substrate for a Polyprenolphosphomannose-Dependent Mycobacterial Mannosyltransferase” Carbohydr. Res. 2007, 342, 1741-1772.
  • Rademacher, C.; Shoemaker, G. K.; Kim, H.-S.; Zheng, R. B.; Taha, H.; Liu, C.; Nacario, R. C.; Schriemer, D. C.; Klassen, J. S.; Peters, T.; Lowary, T. L. “Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan. A model system for oligofuranoside-protein recognition” J. Am. Chem. Soc. 2007, 129, 10489–10502.
  • Joe, M.; Bai, Y.; Nacario, R. C.; Lowary, T. L. “Synthesis of the Docosanasaccharide Arabinan Domain of Mycobacterial Arabinogalactan and a Proposed Octadecasaccharide Biosynthetic Precursor” J. Am. Chem. Soc. 2007, 129, 9885–9901.


  • Joe, M.; Lowary, T. L. “Synthesis of 2-Deoxy-2-fluoro Analogs of Polyprenyl beta-D-Arabinofuranosyl Phosphates” Carbohydr. Res. 2006, 341, 2723–2730.
  • Bai, Y.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Application to alpha-D-Galactofuranosides” J. Org. Chem. 2006, 71, 9658-9671.
  • Bai, Y.; Lowary, T. L. “Synthesis of a Pentasaccharide Fragment of Varianose, a Cell Wall Polysaccharide from Penicllium varians” J. Org. Chem. 2006, 71, 9672-9680.
  • Mendlik, M. T.; Tao, P.; Hadad, C. M.; Coleman, R. S.; Lowary, T. L. “Synthesis of L-Daunosamine and L-Ristosamine Glycosides Via Photoinduced Aziridination.   Conversion to Thioglycosides for Use in Glycosylation Reactions” J. Org. Chem. 200671, 8059-8070.
  • Joe, M.; Sun, D.; Taha, H.; Completo, G. C.; Croudace, J. E.; Lammas, D. A.; Besra, G. S.; Lowary, T. L. “The 5-Deoxy-5-Methylthio-Xylofuranose Residue in Mycobacterial Lipoarabinomannan.   Absolute Stereochemistry, Linkage Position, Ring Conformation and Immunomodulatory Activity” J. Am. Chem. Soc. 2006128, 5059-5072.
  • Rose, N. L.; Completo, G. C.; Lin, S.-J.; McNeil, M. R.; Palcic, M. M.; Lowary, T. L. “Expression, Purification and Characterization of a Galactofuranosyl-transferase Involved in Mycobacterium tuberculosis Arabinogalactan Biosynthesis” J. Am. Chem. Soc. 2006128, 6721-6729.
  • Ridgway, K. M.; Shi, W.; Lin, S.-J.; Palcic, M. M.; Lowary, T. L. “Chemical and Chemoenzymatic Synthesis of a Trisaccharide Fragment of Tsukamurella paurometabola Lipoarabinomannan” Can J. Chem. 200684, 642-649.
  • Bai, Y.; Lin, S.-J.; Qi, G.; Palcic, M. M.; Lowary, T. L. “Synthesis of n-octyl 2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1,2)-3-amino-3-deoxy-beta-D-galactopyranoside, an analog of the H-disaccharide antigen” Carbohydr. Res.2006341, 1702-1707.
  • Chang, G. X.; Lowary, T. L. ” An Olefin Cross Metathesis Approach to -Disaccharide Analogs of the alphaD-arabinofuranosyl-(1,5)-alphaD-arabinofuranoside Motif Found in the Mycobacterial Cell Wall ” Tetrahedron Lett. 200647, 4561-4564.
  • Kim, H.-S.; Ng, E. S. M.; Zheng, R. B.; Whittal, R.; Schriemer, D. C.; Lowary, T. L. “Studies Toward the Development of Anti-tuberculosis Vaccines Based on Mycobacterial Lipoarabinomannan” ACS Symposium Series, 2006


  • Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. “Modified Mannose Disaccharides as Substrates and Inhibitors of a Polyprenol Monophosphomannose-Dependent alpha-(1,6)-Mannosyltransferase Involved in Mycobacterial Lipoarabinomannan Biosynthesis” Bioorg. Med. Chem200513, 1083-1094.
  • Cociorva, O. M.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. “Oligosaccharides as Inhibitors of Mycobacterial Arabinosyltransferases.   Di- and Trisaccharides Containing C-3 Modified Arabinofuranosyl Residues Bioorg. Med. Chem200513, 1369-1379.
  • Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. “Synthetic Disaccharide Analogs as Potential Substrates and Inhibitors of a Mycobacterial Polyprenol Monophosphomannose-Dependent alpha-(1,6)-Mannosyltransferase” Tetrahedron: Asymmetry 200515, 553-567.
  • Completo, G. C.; Ponto, J. A.; Lowary, T. L. “Synthesis of Oligosaccharide Fragments of the Lipoarabinomannan from Rhodocuccus ruber” J. Carbohydr. Chem. 200524, 517-527.
  • Tong, M.; Jacobi, C. E.; van de Rijke, F. M.; Kuijper, S.; van de Werken, S.; Lowary, T. L.; Hokke, C. H.; Appelmelk, B. J.; Nagelkerke, N. J. D.; Hans J. Tanke, van Gijlswijk, R. P. M.; Kolk, A. H. J.; Raap, A. K. “A Multiplexed and Miniaturized Serological Tuberculosis (TB) Assay Identifies Antigens that Discriminate Maximally Between TB and non-TB Sera” J. Immunol. Meth. 200530, 154-163.
  • Luu, T.; Shi, W.; Lowary, T. L.; Tykwinski, R. R. “A Divergent Synthesis of Triyne Natural Products and Glycosylated Analogues Using a Carbenoid Rearrangement” Synthesis 2005, 3167-3178.
  • Fan, E.; Lowary, T. L.; McDonald, R. “(3S,1S)-3-Hydroxyl-3-isopropenyl-1-tert-butyldiphenylsiloxy-1,2,3,4 -tetrahydronaphthalene” Acta Cryst E 200561, o4295-o4297.


  • Cociorva, O. M.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis.   Application to the Preparation of C-2 Functionalized alpha-D-Arabinofuranosides” Tetrahedron 200460, 1481-1489.
  • Cociorva, O. M.; Lowary, T. L. “Synthesis of Oligosaccharides as Potential Inhibitors of Mycobacterial Arabinosyltransferases.   Di- and Trisaccharides Containing C-5 Modified Arabinofuranosyl Residues” Carbohydr. Res. 2004339, 853-865.
  • Centrone, C. A.; Lowary, T. L. “Sulfone and Phosphinic Acid Analogs of Decaprenolphosphoarabinose as Potential Anti-tuberculosis Agents” Bioorg. Med. Chem200412, 5495-5503.
  • Koppel. E. A.; Ludwig, I. S.; Sanchez-Hernandez, M.; Lowary, T. L.; Gadikota, R. R.; Bovin, N.; Vandenbroucke, C. M. J. E, van Looyk, Y.; Appelmelk, B. J.; Geijtenbeek, T. B. H.   “Identification of the Mycobacterial Carbohydrate Structure That Binds the C-type Lectins DC-SIGN, L-SIGN, and SIGNR1 ” Immunobiol. 2004209, 117-127.
  • Tilekar, J. N.; Lowary, T. L. “An Efficient Route to Thioglycosides with the 2,3-Anhydro-DriboStereochemistry” Carbohydr. Res. 2004 339 , 2895-2899.
  • Rhoad, J. S.; Lowary, T. L.; Ferguson, M. J. “5,6,7,9-Tetra--acetyl-4,8-anhydro-1,2,3-trideoxy-DglyceroDgulo-non-1-enitol ” Acta Cryst E. 200460, o1939-o1941.
  • Rhoad, J. S.; Lowary, T. L.; Ferguson, M. J. “4,8-Anhydro-1,2,3,5-tetradeoxy-Dallo-non-1-enitol ” Acta Cryst E. 200460, o1942-o1944.
  • Bai, Y.; Lowary, T. L.; Ferguson, M. J. “-Tolyl 2,3-anhydro-5,6- O-isopropylidene-1-thio-beta-D-gulofuranoside” Acta Cryst E, 200460, o2201-o2203.


  • Houseknecht, J. B.; Lowary, T. L.; Hadad, C. M. “Improved Karplus Equations for 3 C1,H4 in Aldopentofuranosides.   Application to the Conformational Preferences of the Methyl Aldopentofuranosides” J. Phys. Chem. A. 2003107, 372-378.
  • Han, J.; Gadikota, R. R.; McCarren, P. R.; Lowary, T. L. “Synthesis of Octyl Arabinofuranosides as Substrates for Mycobacterial Arabinosyltransferases” Carbohydr. Res. 2003338, 581-588.
  • Gadikota, R. R.; Keller, A. I.; Callam, C. S.; Lowary, T. L. “Efficient syntheses of trans -(+)-laurediol from carbohydrate precursors” Tetrahedron: Asymmetry 200314,737-742.
  • Gadikota, R. R.; Callam, C. S.; Appelmelk, B. J.; Lowary, T. L. “Synthesis of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan Appropriately Functionalized for Neoglycoconjugate Preparation” J. Carbohydr. Chem. 200322, 459-480.
  • Gadikota, R. R.; Callam, C. S.; Wagner, T.; Del Fraino, B.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. Highly Stereocontrolled Synthesis of Oligosaccharides Containing alpha and beta Arabinofuranosyl Linkages” J. Am. Chem. Soc. 2003125, 4155-4165.
  • Han, J.; Lowary, T. L. “Total Synthesis of Buergerinin F and Buergerinin G” J. Org. Chem. 200368, 4116-4119.
  • Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “An Efficient Route to Pyrimidine Nucleosides with the 2,3-Anhydro-beta-Dlyxofuranosyl Stereochemistry ” Synlett, 2003, 1271-1274.
  • Houseknecht, J. B.; Lowary, T. L.; Hadad, C. M. “Gas and Solution Phase Energetics of the Methyl alpha and beta-D -aldopentofuranosides ” J. Phys. Chem. A. 2003107, 5763-5777.
  • Centrone, C. A.; Lowary, T. L. “An Efficient Route for the Synthesis of Glycosyl Phosphinic Acids” J. Org. Chem200368, 8115-8119.
  • Callam, C. S.; Gadikota, R. R.; Krein, D. M.; Lowary, T. L. “2,3-Anhydrosugars in Glycoside Bond Synthesis. NMR and Computational Investigations into the Mechanism of Glycosylations with 2,3-Anhydrofuranosyl Glycosyl Sulfoxides” J. Am. Chem. Soc. 2003125, 13112-13119.
  • Darwish, O.; Callam, C. S.; Hadad. C. M.; Lowary, T. L. “Regioselectivity in Alkylation Reactions of 1,2-O-Stannylene Acetals of D-Arabinofuranose” J. Carbohydr. Chem. 200322, 955-973.
  • Lowary, T. L. “Recent Progress Towards the Identification of Inhibitors of Mycobacterial Cell Wall Polysaccharide Biosynthesis” Mini-Rev. Med. Chem. 20033, 694-707.
  • Lowary, T. L. “Synthesis and Conformational Analysis of Arabinofuranosides, Galactofuranosides, and Fructofuranosides” Curr. Opin. Chem. Biol. 20037, 749-756.
  • Wagner, T.; Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “1-(2´,3´-anhydro-5´-O-benzoyl-beta-D-lyxofuranoyl)-5-fluoro-uracil ” Acta Cryst E. 200359, o1063-o1065.


  • Lowary, T. L.; Eichler, E., Bundle, D. R. “Oligosaccharide Recognition by Antibodies: Synthesis and Evaluation of Talose Oligosaccharide Analogues” Can. J. Chem. 200280, 1112-1130.
  • Yin, H.; D’Souza, F. W.; Lowary, T. L. “Arabinofuranosides from Mycobacteria: Synthesis of a Highly Branched Hexasaccharide and Related Fragments Containing beta-Arabinofuranosyl Residues” J. Org. Chem200267, 892-903.
  • Lowary, T. L. “D-Arabinofuranosides from Mycobacteria: Synthesis and Conformation” J. Carbohydr. Chem. 200221, 691-722.
  • Houseknecht, J. B.; Lowary, T. L. “Oligofuranosides Containing Conformationally-Restricted Residues: Synthesis and Conformational Analysis” J. Org. Chem200267, 4150-4164.
  • Houseknecht, J. B.; Altona, C.; Hadad, C. M.; Lowary, T. L. “Conformational Analysis of Furanose Rings with PSEUROT: Parameterization for Rings Possessing the Arabino-, Lyxo-, Ribo– and Xylo– Stereochemistry and Application toArabinofuranosides ” J. Org. Chem200267, 4647 -4651.
  • Krein, D. M.; Lowary, T. L. “An Efficient Route to 2-(Alkylamino)pyridines” J. Org. Chem200267, 4965-4967.
  • Kaur, D.; Lowary, T. L.; Vissa, V. D.; Crick, D. C.; Brennan, P. J. “Characterization of the Epitope of Anti-lipoarabinomannan Antibodies as the Terminal Hexaarabinofuranosyl Motif of Mycobacterial Arabinans” Microbiology UK2002148, 3059-3067.
  • Basak, P.; Lowary, T. L.”Synthesis of Conjugates of -Fucose and ortho-Carborane as Potential Agents for Boron Neutron Capture Therapy” Can. J. Chem. 200280, 943-948.
  • Centrone, C. A.; Lowary, T. L. “Synthesis and Anti-tuberculosis Activity of C-Phosphonate Analogs of Decaprenolphosphoarabinose, A Key Intermediate in the Biosynthesis of Mycobacterial Arabinogalactan and Lipoarabinomannan” J. Org. Chem200267, 8862-8870.


  • Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “An Efficient Synthesis of Methyl 2,3-anhydro-alpha-D-ribofuranosideCarbohydr. Res. 2001330, 267-270.
  • Callam, C. S.; Lowary, T. L. “Synthesis of Methyl 2,3,5-tri-O-benzoyl-alpha-D-arabinofuranoside in the Organic Laboratory ” J. Chem. Educ. 200178, 73-74.
  • Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “Stereocontrolled Synthesis of 2,3-Anhydro-beta-D-lyxofuranosyl Glycosides” Org. Lett. 20013, 607-610.
  • McGurk, P.; Chang, G. X.; Lowary, T. L.; McNeil, M.; Field, R. A. “Stereospecific Synthesis of 5-Phospho-alpha-D-arabinosyl-C– phosphonophosphate (pApp): A Stable Analogue of the Putative Mycobacterial Cell Wall Biosynthetic Intermediate 5-Phospho-D-arabinosyl Pyrophosphate” Tetrahedron Lett. 200142, 2231-2234
  • McCarren, P. R.; Gordon, M. T.; Lowary, T. L.; Hadad, C. M. “Computational Studies of the Arabinofuranose Ring: Conformational Preferences of Fully Relaxed Methyl alpha-D -arabinofuranoside ” J. Phys. Chem. A. 2001105, 5911-5922.
  • Callam, C. S.; Lowary, T. L. “Suzuki Cross Coupling Reactions: Synthesis of Unsymmetrical Biaryls in the Organic Laboratory” J. Chem. Educ. 200178, 947-948.
  • Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “Sensitivity of 1JC1H1 Magnitudes to Anomeric Stereochemistry in 2,3-Anhydro-O-furanosides” J. Org. Chem. 200166, 4549-4558.
  • Lowary, T. L. “Mycobacterial Cell Wall Polysaccharides: Structure, Function, Biosynthesis and New Opportunities for Drug Design” Invited Chapter in Glycoscience: Chemistry and Chemical Biology Fraser-Reid, B; Thiem, J.; Tatsuta, K. Eds. Springer-Verlag, 2001.
  • Lowary, T. L. “D-Arabinofuranosides from Mycobacteria: Synthesis and Conformation” Invited Chapter in Glycochemistry: Synthesis and Applications Bertozzi, C. R.; Wang, P. Eds. Marcel-Dekker, 2001.
  • Houseknecht, J. B.; Lowary, T. L. ” Chemistry and Biology of Arabinofuranosyl and Galactofuranosyl-Containing Polysaccharides ” Curr. Opin. Chem. Biol. 2001 , 677-682.
  • Yin, H. F.; Lowary, T. L. “Synthesis of arabinofuranosides via low-temperature activation of thioglycosides” Tetrahedron Lett. 200142, 5829-5832.
  • Houseknecht, J. B.; McCarren, P. R.; Lowary, T. L.; Hadad, C. M. ” Conformational Studies of Methyl 3-O-Methyl-alpha-D-Arabinofuranoside: An Approach for Studying the Conformation of Furanose Rings” J. Am. Chem. Soc. 2001123, 8811-8824.
  • Callam, C. S.; Singer, S. J.; Lowary, T. L.; Hadad, C. M. “Computational Analysis of the Potential Energy Surfaces of Glycerol in the Gas and Aqueous Phases.   Effects of Level of Theory and Basis Set on Strongly Intramolecular Hydrogen-Bonded Systems ” J. Am. Chem. Soc. 2001123, 11743-11754.
  • Callam, C. S.; Lowary, T. L. “Synthesis and Conformational Investigations of Methyl 4a-carba-D-arabinofuranosidesJ. Org. Chem. 200166, 8961-8972.
  • Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “Total Synthesis of (6S,7S,9S,10S)-6,9-epoxynonadec-18-ene-7,10-diol and Formal Total Synthesis of (+)- trans-Kumausyne from D-Arabinose” J. Org. Chem200166, 9046-9051.


  • Laferté, S.; Chan, N. W. C.; Sujino, K.; Lowary, T. L.; Palcic, M. M. “Intracellular Inhibition of Blood Group A Glycosyltransferase” Eur. J. Biochem. 2000267, 4840-4849.
  • Callam, C. S.; Lowary, T. L. “Total Synthesis of Methyl 4a-carba-D-arabinofuranosides” Org. Lett. 20002, 167-169.
  • Davis, T. M.; Lowary, T. L. “Unexpected Formation of Glycals Upon Attempted C-alkylation of Protected Glycosylacetylenes” Carbohydr. Res2000324, 210-217.
  • D’Souza, F. W.; Ayers, J. D.; McCarren, P. R.; Lowary, T. L. “Arabinofuranosyl Oligosaccharides from Mycobacteria: Synthesis and Effect of Glycosylation on Ring Conformation and Hydroxymethyl Group Rotamer Populations” J. Am. Chem. Soc. 2000122, 1251-1260.
  • D’Souza, F. W.; Lowary, T. L. “The First Total Synthesis of a Highly Branched Arabinofuranosyl Hexasaccharide Found at the Nonreducing Termini of Mycobacterial Arabinogalactan and Lipoarabinomannan” Org. Lett. 20002, 1493-1495.
  • Chang, G. X.; Lowary, T. L. “A Glycosylation Protocol Based on Activation of Glycosyl 2-Pyridyl Sulfones with Samarium Triflate” Org. Lett. 20002, 1505-1508.
  • Gordon, M. T.; Lowary, T. L.; Hadad, C. M. “Probing Furanose Ring Conformation by Gas-Phase Computational Methods: Energy Profile and Structural Parameters in Methyl beta-D-arabinofuranoside as a Function of Ring Conformation” J. Org. Chem. 200065, 4954-4963.
  • Gallucci, J. C.; Gadikota, R. R.; Lowary, T. L. ” p-Cresyl 2,3-anhydro-5-deoxy-5-phthalimido-1-thio-alpha-D-lyxofuranoside ” Acta. Cryst. C. 200056, e365.

1988 - 1998


  • Subramaniam, V.; Lowary, T. L. “Synthesis of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan from Mycobacterium tuberculosis” Tetrahedron, 199955, 5965-5976.
  • Gordon, M. T.; Lowary, T. L.; Hadad, C. M. “A Computational Study of Methyl alpha-D-Arabinofuranoside: Effect of Ring Conformation on Structural Parameters and Energy Profile” J. Am. Chem. Soc. 1999121, 9682-9692.


  • Lowary, T. L.; Meldal, M. Helmboldt, A.; Vasella, A.; Bock, K. “Novel Rigid Type of C-linked Glycosylacetylene Phenylalanine Building Blocks for Combinatorial Syntheses of C-Linked Glycopeptides” J. Org. Chem. 199863, 9657-9668.
  • St. Hilaire, P. M.; Lowary, T. L.; Meldal, M.; Bock, K. “Oligosaccharide Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide Libraries” J. Am. Chem. Soc. 1998120, 13312-13320.
  • Ayers, J. D.; Lowary, T. L.; Morehouse, C. B.; Besra, G. S. “Recognition of Synthetic Synthetic Arabinofuranosyl Oligosaccharides by Mycobacterial Arabinosyltransferases ” Bioorg. Med. Chem. Lett. 19988, 437-442.
  • D’Souza, F. W.; Lowary, T. L. “A New Route to Carbohydrates Enriched with Oxygen Isotopes” J. Org. Chem. 199863, 3166-3167.
  • Bausch, C.; Peekhaus, N.; Utz, C.; Blais, T.; Murray, E.; Lowary, T. L.; Conway, T. “Post-Genomic Analysis of the GntII (Subsidiary) System for Gluconate Metabolism Reveals a Novel Pathway for L-Idonic Acid Catabolism in E. coli” J. Bacteriol. 1998180, 3704-3710.
  • D’Souza, F. W.; Cheshev, P. E.; Ayers, J. D.; Lowary, T. L. “Conversion of Pyranose Glycals to Furanose Derivatives: A New Route to Oligofuranosides” J. Org. Chem. 199863, 9037-9044.


  • Greis, K. D.; Hayes, B. K.; Comer, F. I.; Kirk, M.; Barnes, S.; Lowary, T. L.; Hart, G. W. “Selective Detection of Glycopeptides and Site Mapping by Electrospray Mass Spectrometry” Anal. Biochem. 1996234, 38-49.


  • Deng, S.-J.; McKenzie, C. R.; Hirama, T.; Brousseau, R.; Young, N. M.; Lowary, T. L.; Bundle, D. R.; Narang, S. A. “A Synthetic Gene Library Approach to the Enhancement of Antibody Affinity” Proc. Natl. Acad. Sci. USA 199592, 4992-4996.
  • Lowary, T. L.; Eichler, E.; Bundle, D. R. “Preparation of a Pentasaccharide Antigen for the Investigation of Carbohydrate-Protein Interactions” J. Org. Chem. 199560, 7316-7327.
  • Peters, S.; Lowary, T. L.; Hindsgaul, O.; Meldal, M.; Bock, K. “Solid Phase Synthesis of a Fucosylated Glycopeptide of Human Factor IX with a Fucose-alpha-(1,O)-Serine Linkage” J. Chem. Soc. Perkin Trans. 1 1995, 3017-3022.


  • Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic O-methyl, Epimeric and Amino Analogs of the Acceptor alpha-L-Fucp-(1,2)-beta-D-Galp-OR by the Blood-Group A and B Gene-Specified Glycosyltransferases” Carbohydr. Res. 1994251, 33-67.
  • Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic Analogs of the Acceptor beta-D-Galp-OR by the Blood-Group H Gene-Specified Glycosyltransferase” Carbohydr. Res. 1994256, 257-273.
  • Lowary, T. L.; Bundle, D. R. “Nucleophile Induced Rearrangements of Thioglycosides: Formation of 6-Thio Glycosides and 1,6 Thioanhydrosugars” Tetrahedron:Asymmetry 199412, 2397-2404.


  • Lowary, T. L.; Hindsgaul, O. “Recognition of Synthetic Deoxy and Deoxyfluoro Analogs of the Acceptor alpha-L-Fucp-(1,2)- beta-D-Galp-OR by the Blood-Group A and B Gene-Specified Glycosyltransferases” Carbohydr. Res. 1993249, 163-195.


  • Lowary, T. L.; Richards, G. N. “Cycloheptaamylose as a Model for Starch in the Pyrolysis of Polysaccharides” Carbohydr. Res. 1991218, 157-166.


  • Lowary, T. L.; Richards, G. N. “Mechanisms of Pyrolysis of Polysaccharides: Cellobiitol as a Model for CelluloseCarbohydr. Res. 1990198, 79-89.


  • Lowary, T. L.; Richards, G. N. “Analysis of a Hydroxystilbene Glucoside in Several Softwood Barks” J. Wood Chem. and Tech. 19899, 333-340.


  • Lowary, T. L.; Richards, G. N. “Effects of Impurities on the Hydrolysis of Sucrose in Concentrated Aqueous Solution” Int. Sugar J. 198890, 164-167.
  • Lowary, T. L.; Richards, G. N. “Vacuum Pyrolysis of Bark from Pinus ponderosa” J. Wood Chem. and Tech. 19888, 393-412

Scroll to Top